Genomic functional annotation using co-evolution profiles of gene clusters

The current speed of sequencing already exceeds the capability of annotation. A new method for functional annotation is proposed using the conservation patterns of gene clusters and has been applied to the genome of Escherichia coli and established functional relationships among 176 gene clusters, c...

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Bibliographic Details
Main Authors: Zheng, Yu, Roberts, Richard J, Kasif, Simon
Format: Online
Language:English
Published: BioMed Central 2002
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133444/