Perforin deficiency attenuates collagen-induced arthritis

Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruc...

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Bibliographic Details
Main Authors: Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, Mix, Eilhard, Thiesen, Hans-Juergen, Holmdahl, Rikard, Ibrahim, Saleh M
Format: Online
Language:English
Published: BioMed Central 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175039/