Perforin deficiency attenuates collagen-induced arthritis
Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruc...
Main Authors: | , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
BioMed Central
2005
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175039/ |