RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have emerged approximately 500 million years ago from transposon-encoded proteins. Yet no transposase sequence similar to RAG1 or RAG2 has been found. Here we show that the approxi...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2005
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131882/ |