V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins

V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins

Antigen receptor gene rearrangement is directed by DNA motifs consisting of a conserved heptamer and nonamer separated by a nonconserved spacer of either 12 or 23 base pairs (12 or 23 recombination signal sequences [RSS]). V(D)J recombination requires that the rearranging DNA segments be flanked by...

Full description

Bibliographic Details
Main Authors: Sawchuk, Dennis J., Weis-Garcia, Frances, Malik, Sohail, Besmer, Eva, Bustin, Michael, Nussenzweig, Michel C., Cortes, Patricia
Format: Online
Language:English
Published: The Rockefeller University Press 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196333/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196333/

Similar Items