Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters
The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline–nickel complex, and cyclization is enabled by the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH Verlag
2018
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| Online Access: | http://eprints.nottingham.ac.uk/53504/ http://eprints.nottingham.ac.uk/53504/ http://eprints.nottingham.ac.uk/53504/ http://eprints.nottingham.ac.uk/53504/1/HWL%20Ni-desymmetrization%20of%20malonates%20ACIE%20manuscript.pdf |