Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
Mitochondrial Ca2+ homoeostasis regulates aerobic metabolism and cell survival. Ca2+ flux into mitochondria is mediated by the mitochondrial calcium uniporter (MCU) channel whereas Ca2+ export is often through an electrogenic Na+–Ca2+ exchanger. Here, we report remarkable functional versatility in m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018
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| Online Access: | http://eprints.nottingham.ac.uk/49080/ http://eprints.nottingham.ac.uk/49080/ http://eprints.nottingham.ac.uk/49080/ http://eprints.nottingham.ac.uk/49080/1/Samanta-et-al-2017%20mitochondrial%20calcium%20oscillations.pdf |