Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease
A number of genetic loci associate with early onset Alzheimer’s disease (EOAD), however the drivers of this disease remains enigmatic. Genome wide association and in-vivo modelling have shown that loss-of-function e.g. ABCA7, reduced levels of SIRT1, MEFF2C or increases levels of PTK2β confer risk o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2017
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| Online Access: | http://eprints.nottingham.ac.uk/45002/ http://eprints.nottingham.ac.uk/45002/ http://eprints.nottingham.ac.uk/45002/ http://eprints.nottingham.ac.uk/45002/8/adr%252F2017%252F1-1%252Fadr-1-1-adr170015%252Fadr-1-adr170015.pdf |