A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Bibliographic Details
Main Authors: Barthelme, Alexandre, Richards, David, Mellor, Ian R., Stockman, Robert A.
Format: Article
Language:English
Published: Royal Society of Chemistry 2013
Online Access:http://eprints.nottingham.ac.uk/35316/
http://eprints.nottingham.ac.uk/35316/
http://eprints.nottingham.ac.uk/35316/
http://eprints.nottingham.ac.uk/35316/1/ChemComm%202013.pdf