The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments
The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations to investigate how the compound affects cells in ea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012
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| Online Access: | http://eprints.nottingham.ac.uk/2395/ http://eprints.nottingham.ac.uk/2395/ http://eprints.nottingham.ac.uk/2395/ http://eprints.nottingham.ac.uk/2395/1/theoreticalbiology.pdf |