The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

Abstract Mutations in the telomerase reverse transcriptase gene promoter (TERTp) are common in glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in tumorigenesis and may be of prognostic value. However, the extent of their prognostic importance in various gliomas is...

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Bibliographic Details
Main Authors: Yujin Lee, Jaemoon Koh, Seong-Ik Kim, Jae Kyung Won, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park
Format: Article
Language:English
Published: BioMed Central 2017-08-01
Series:Acta Neuropathologica Communications
Subjects:
Telomerase reverse transcriptase
Alpha-thalassemia/mental retardation syndrome X-linked (ATRX)
Anaplastic astrocytoma
Glioblastoma
Isocitrate dehydrogenase (IDH)
Oligodendroglioma
Online Access:http://link.springer.com/article/10.1186/s40478-017-0465-1

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http://link.springer.com/article/10.1186/s40478-017-0465-1

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