Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours

Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours

Abstract Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly detrimental in oncology where rearrangements...

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Bibliographic Details
Main Authors: Louise Harewood, Kamal Kishore, Matthew D. Eldridge, Steven Wingett, Danita Pearson, Stefan Schoenfelder, V. Peter Collins, Peter Fraser
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:Genome Biology
Subjects:
Hi-C
Chromosome conformation capture
Cancer
Tumour
Glioblastoma
Anaplastic astrocytoma
Online Access:http://link.springer.com/article/10.1186/s13059-017-1253-8

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http://link.springer.com/article/10.1186/s13059-017-1253-8

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