Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

Abstract Background Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amino acid polypeptide, which attaches covalently to target proteins thr...

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Bibliographic Details
Main Authors: Jagrati Jain, Surendra K. Jain, Larry A. Walker, Babu L. Tekwani
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:BMC Pharmacology and Toxicology
Subjects:
Malaria
Plasmodium falciparum
Ubiquitine
Proteasome
Ubiquitine E3 ligase
Antimalarial
Online Access:http://link.springer.com/article/10.1186/s40360-017-0147-4

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http://link.springer.com/article/10.1186/s40360-017-0147-4

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