HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function

HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function

Abstract Virus-infected cells can regulate non-permissive bystander cells, but the precise mechanisms remain incompletely understood. Here we report that this process can be mediated by transfer of viral RNA-loaded exosomes shed from infected cells to myeloid-derived suppressor cells (MDSCs), which...

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Bibliographic Details
Main Authors: Lin Wang, Dechao Cao, Ling Wang, Juan Zhao, Lam Nhat Nguyen, Xindi Dang, Yingjie Ji, Xiao Y. Wu, Zheng D. Morrison, Qian Xie, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Cell Discovery
Online Access:http://link.springer.com/article/10.1038/s41421-018-0052-z

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http://link.springer.com/article/10.1038/s41421-018-0052-z

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