Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

Abstract T cells play a crucial role in viral clearance and vaccine responses; however, the mechanisms that regulate their homeostasis during viral infections remain unclear. In this study, we investigated the machineries of T-cell homeostasis and telomeric DNA damage using a human model of hepatiti...

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Bibliographic Details
Main Authors: Lam Nhat Nguyen, Juan Zhao, Dechao Cao, Xindi Dang, Ling Wang, Jianqi Lian, Ying Zhang, Zhansheng Jia, Xiao Y. Wu, Zheng Morrison, Qian Xie, Yingjie Ji, Zheng Zhang, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Cell Death and Disease
Online Access:http://link.springer.com/article/10.1038/s41419-018-0897-y

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http://link.springer.com/article/10.1038/s41419-018-0897-y

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