Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR

Abstract Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations in the CFTR chloride channel, the most frequent of which is Phe508del. Phe508del causes not only intracellular retention and premature degradation of the mutant CFTR protein, but also defective cha...

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Bibliographic Details
Main Authors: Ana M. Matos, Andreia Gomes-Duarte, Márcia Faria, Patrícia Barros, Peter Jordan, Margarida D. Amaral, Paulo Matos
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:http://link.springer.com/article/10.1038/s41598-018-31514-2

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http://link.springer.com/article/10.1038/s41598-018-31514-2

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