Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients

Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients

Abstract Background YAP, a potent oncogene and major downstream effector of the mammalian Hippo tumor suppressor pathway can act as either oncogene or tumor suppressor gene based on the type of tissue involved. Despite various studies, the role and mechanism through which YAP mediates its tumor supp...

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Bibliographic Details
Main Authors: Sumayya Abdul Sattar Real, Farah Parveen, Asad Ur Rehman, Mohammad Aasif Khan, Sankaravamasam Venkata Suryanarayan Deo, Nootan Kumar Shukla, Syed Akhtar Husain
Format: Article
Language:English
Published: BioMed Central 2018-07-01
Series:BMC Cancer
Subjects:
Downregulation
Hippo pathway
mRNA
Tumor suppressor gene
YAP
Online Access:http://link.springer.com/article/10.1186/s12885-018-4627-8

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