The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

Abstract Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we use different Drosophila melanogaster eye cancer m...

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Bibliographic Details
Main Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:Journal of Hematology & Oncology
Subjects:
CCR4-NOT
Leukemia
mRNA stability
Tumor suppressor
Drosophila melanogaster
Online Access:http://link.springer.com/article/10.1186/s13045-018-0650-0

Internet

http://link.springer.com/article/10.1186/s13045-018-0650-0

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