Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique

Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique

Abstract Background We describe the accumulation of HIV-1 drug resistance and its effect on the activity of next-line components in patients with virological failure (HIV-1 RNA >1000 copies/mL) after 1 year (t1) of first-line antiretroviral therapy (ART) not switching to second-line drugs for one...

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Bibliographic Details
Main Authors: Andrea De Luca, Zita Jorge Sidumo, Giacomo Zanelli, Noorjehan Abdul Magid, Richard Luhanga, Davide Brambilla, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi, Leonardo Palombi, Susanna Ceffa
Format: Article
Language:English
Published: BioMed Central 2017-09-01
Series:BMC Infectious Diseases
Subjects:
HIV-1
Antiretroviral drug resistance
Second-line ART
Virological failure
HIV-1 RNA
Online Access:http://link.springer.com/article/10.1186/s12879-017-2709-x

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http://link.springer.com/article/10.1186/s12879-017-2709-x

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