Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

Abstract Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease. The ability of metabotropic glutamate (mGlu) receptors to modulate...

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Bibliographic Details
Main Authors: James Maksymetz, Sean P. Moran, P. Jeffrey Conn
Format: Article
Language:English
Published: BioMed Central 2017-04-01
Series:Molecular Brain
Subjects:
mGlu receptor
Schizophrenia
Allosteric modulator
Signal bias
Heterodimer
PAM
Online Access:http://link.springer.com/article/10.1186/s13041-017-0293-z

Internet

http://link.springer.com/article/10.1186/s13041-017-0293-z

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