Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Abstract Background The irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan. Methods Phosphokinome profiling with peptide arrays of tumour samples from nude mice xenografted with HT2...

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Bibliographic Details
Main Authors: Diego Tosi, Esther Pérez-Gracia, Salima Atis, Nadia Vié, Eve Combès, Mélissa Gabanou, Christel Larbouret, Marta Jarlier, Caroline Mollevi, Adeline Torro, Maguy Del Rio, Pierre Martineau, Céline Gongora
Format: Article
Language:English
Published: BioMed Central 2018-08-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Drug combinations
Phosphokinome
Irinotecan
Synergistic effect
Online Access:http://link.springer.com/article/10.1186/s12885-018-4712-z

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