Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic ß-cell line and mouse islets
Interleukin-6 (IL6) has recently been reported to promote insulin secretion in a glucagon-like peptide-1-dependent manner. Herein, the direct effects of IL6 (at various concentrations from 0 to 1000 pg/ml) on pancreatic β-cell metabolism, AMP-activated protein kinase (AMPK) signaling, insulin secret...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
BioScientifica Ltd.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/19062 |