The potential role of free chitosan in bone trauma and bone cancer management
Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases oste...
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| Format: | Journal Article |
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Elsevier Ltd
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/41787 |
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curtin-20.500.11937-41787 |
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eprints |
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curtin-20.500.11937-417872017-09-13T14:19:00Z The potential role of free chitosan in bone trauma and bone cancer management Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collagen I expression, and reduces osteoclastogenesis. Chitosan inhibits invasion of endothelial cells, downregulating uPA/R, MT1-MMP, cdc42 and Rac1. Better healing of bone fractures with greater trabecular bone formation was observed in mice treated with chitosan. Chitosan induces apoptosis in osteotropic prostate and breast cancer cells via caspase-2 and -3 activation, and reduces their establishment in bone. Chitosan is pro-apoptotic in osteosarcoma cells, but not their normal counterpart, osteoblasts, or chondrosarcoma cells. Systemic delivery of chitosan does not perturb angiogenesis, bone volume or instinctive behaviour in pregnant mice, but decreases foetal length and changes pancreatic secretory acini. With certain controls in place, chitosan could be useful for bone trauma management. 2014 Journal Article http://hdl.handle.net/20.500.11937/41787 10.1016/j.biomaterials.2014.05.087 Elsevier Ltd restricted |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Curtin University Malaysia |
| building |
Curtin Institutional Repository |
| collection |
Online Access |
| topic |
Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis |
| spellingShingle |
Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin The potential role of free chitosan in bone trauma and bone cancer management |
| description |
Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collagen I expression, and reduces osteoclastogenesis. Chitosan inhibits invasion of endothelial cells, downregulating uPA/R, MT1-MMP, cdc42 and Rac1. Better healing of bone fractures with greater trabecular bone formation was observed in mice treated with chitosan. Chitosan induces apoptosis in osteotropic prostate and breast cancer cells via caspase-2 and -3 activation, and reduces their establishment in bone. Chitosan is pro-apoptotic in osteosarcoma cells, but not their normal counterpart, osteoblasts, or chondrosarcoma cells. Systemic delivery of chitosan does not perturb angiogenesis, bone volume or instinctive behaviour in pregnant mice, but decreases foetal length and changes pancreatic secretory acini. With certain controls in place, chitosan could be useful for bone trauma management. |
| format |
Journal Article |
| author |
Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin |
| author_facet |
Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin |
| author_sort |
Tan, M. |
| title |
The potential role of free chitosan in bone trauma and bone cancer management |
| title_short |
The potential role of free chitosan in bone trauma and bone cancer management |
| title_full |
The potential role of free chitosan in bone trauma and bone cancer management |
| title_fullStr |
The potential role of free chitosan in bone trauma and bone cancer management |
| title_full_unstemmed |
The potential role of free chitosan in bone trauma and bone cancer management |
| title_sort |
potential role of free chitosan in bone trauma and bone cancer management |
| publisher |
Elsevier Ltd |
| publishDate |
2014 |
| url |
http://hdl.handle.net/20.500.11937/41787 |
| first_indexed |
2018-09-06T23:14:51Z |
| last_indexed |
2018-09-06T23:14:51Z |
| _version_ |
1610901819146371072 |