γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

Angiogenesis is one of the key hallmarks of cancer. In this study, we investigated whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms. We observed that γ-tocotrienol inhibited vascular endothelial growt...

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Bibliographic Details
Main Authors: Siveen, K., Ahn, K., Ong, T., Shanmugam, M., Li, F., Yap, W., Kumar, Alan Prem, Fong, C., Tergaonkar, V., Hui, K., Sethi, G.
Format: Journal Article
Published: Impact Journals LLC 2014
Online Access:http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1876
http://hdl.handle.net/20.500.11937/16896

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