Mouse Models of Aneuploidy

by Sheppard, Olivia, Wiseman, Frances K., Ruparelia, Aarti, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C.
Published 2012

Down syndrome: searching for the genetic culprits

by Lana-Elola, Eva, Watson-Scales, Sheona D., Fisher, Elizabeth M. C., Tybulewicz, Victor L. J.
Published 2011

Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

by Ruparelia, Aarti, Wiseman, Frances, Sheppard, Olivia, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.
Published 2010

Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival

by Ackermann, Jochen A., Nys, Josquin, Schweighoffer, Edina, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L. J.
Published 2015

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival

by Jacque, Emilie, Schweighoffer, Edina, Tybulewicz, Victor L.J., Ley, Steven C.
Published 2015

Themis2 Is Not Required for B Cell Development, Activation, and Antibody Responses

by Hartweger, Harald, Schweighoffer, Edina, Davidson, Sophia, Peirce, Matthew J., Wack, Andreas, Tybulewicz, Victor L. J.
Published 2014

Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

by Turner, Martin, Gulbranson-Judge, Adam, Quinn, Marian E., Walters, Alice E., MacLennan, Ian C.M., Tybulewicz, Victor L.J.
Published 1997

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

by Reynolds, Lucinda F., Smyth, Lesley A., Norton, Trisha, Freshney, Norman, Downward, Julian, Kioussis, Dimitris, Tybulewicz, Victor L.J.
Published 2002

Syk-Mediated Translocation of PI3Kδ to the Leading Edge Controls Lamellipodium Formation and Migration of Leukocytes

by Schymeinsky, Jürgen, Then, Cornelia, Sindrilaru, Anca, Gerstl, Ronald, Jakus, Zoltán, Tybulewicz, Victor L. J., Scharffetter-Kochanek, Karin, Walzog, Barbara
Published 2007

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

by Duchon, Arnaud, Pothion, Stéphanie, Brault, Véronique, Sharp, Andrew J., Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Herault, Yann
Published 2011

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

by Schweighoffer, Edina, Vanes, Lesley, Nys, Josquin, Cantrell, Doreen, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L.J.
Published 2013

Vav1 GEF activity is required for T cell mediated allograft rejection

by Haubert, Dirk, Li, Jianping, Saveliev, Alexander, Calzascia, Thomas, Sutter, Esther, Metzler, Barbara, Kaiser, Daniel, Tybulewicz, Victor L.J., Weckbecker, Gisbert
Published 2012

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

by Hall, Jessica H., Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Harwood, John L., Good, Mark A.
Published 2016

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

by Crowley, Mary T., Costello, Patrick S., Fitzer-Attas, Cheryl J., Turner, Martin, Meng, Fanying, Lowell, Clifford, Tybulewicz, Victor L. J., DeFranco, Anthony L.
Published 1997

β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination

by Nodari, Alessandro, Zambroni, Desirée, Quattrini, Angelo, Court, Felipe A., D'Urso, Alessandra, Recchia, Alessandra, Tybulewicz, Victor L.J., Wrabetz, Lawrence, Feltri, M. Laura
Published 2007

Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

by Zou, Wei, Kitaura, Hideki, Reeve, Jennifer, Long, Fanxin, Tybulewicz, Victor L.J., Shattil, Sanford J., Ginsberg, Mark H., Ross, F. Patrick, Teitelbaum, Steven L.
Published 2007

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

by Sheppard, Olivia, Plattner, Florian, Rubin, Anna, Slender, Amy, Linehan, Jacqueline M., Brandner, Sebastian, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Wiseman, Frances K.
Published 2012

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

by Ahmed, Md. Mahiuddin, Dhanasekaran, A. Ranjitha, Tong, Suhong, Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Gardiner, Katheleen J.
Published 2013

Mechanism and function of Vav1 localisation in TCR signalling

by Ksionda, Olga, Saveliev, Alexander, Köchl, Robert, Rapley, Jonathan, Faroudi, Mustapha, Smith-Garvin, Jennifer E., Wülfing, Christoph, Rittinger, Katrin, Carter, Tom, Tybulewicz, Victor L. J.
Published 2012

Alterations to Dendritic Spine Morphology, but Not Dendrite Patterning, of Cortical Projection Neurons in Tc1 and Ts1Rhr Mouse Models of Down Syndrome

by Haas, Matilda A., Bell, Donald, Slender, Amy, Lana-Elola, Eva, Watson-Scales, Sheona, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Guillemot, François
Published 2013