Mechanism and function of Vav1 localisation in TCR signalling

Mechanism and function of Vav1 localisation in TCR signalling

The antigen-specific binding of T cells to antigen presenting cells results in recruitment of signalling proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) si...

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Bibliographic Details
Main Authors: Ksionda, Olga, Saveliev, Alexander, Köchl, Robert, Rapley, Jonathan, Faroudi, Mustapha, Smith-Garvin, Jennifer E., Wülfing, Christoph, Rittinger, Katrin, Carter, Tom, Tybulewicz, Victor L. J.
Format: Online
Language:English
Published: The Company of Biologists 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561853/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561853/

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