Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers

by Rahman, Khondaker M., James, Colin H., Thurston, David E.
Published 2011

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-...

by Rosado, Helena, Rahman, Khondaker M., Feuerbaum, Eva-Anne, Hinds, Jason, Thurston, David E., Taylor, Peter W.
Published 2011

Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments

by Mantaj, Julia, Jackson, Paul J. M., Karu, Kersti, Rahman, Khondaker M., Thurston, David E.
Published 2016

Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes

by Rahman, Khondaker M., Corcoran, David B., Bui, Tam T. T., Jackson, Paul J. M., Thurston, David E.
Published 2014

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]be...

by Clingen, Peter H., De Silva, Inusha U., McHugh, Peter J., Ghadessy, Farid J, Tilby, Michael J., Thurston, David E., Hartley, John A.
Published 2005

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

by Mellinas-Gomez, Maria, Spanswick, Victoria J., Paredes-Moscosso, Solange R., Robson, Matthew, Pedley, R. Barbara, Thurston, David E., Baines, Stephen J., Stell, Anneliese, Hartley, John A.
Published 2015

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

by Rahman, Khondaker M., Rosado, Helena, Moreira, Joao B., Feuerbaum, Eva-Anne, Fox, Keith R., Stecher, Eva, Howard, Philip W., Gregson, Stephen J., James, Colin H., de la Fuente, Maria, Waldron, Denise E., Thurston, David E., Taylor, Peter W.
Published 2012