Recent developments in chemical diversity

by Porco, John A
Published 2012

Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A

by Qi, Chao, Qin, Tian, Suzuki, Daisuke, Porco, John A.
Published 2014

Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction

by Grenning, Alexander J., Snyder, John K., Porco, John A.
Published 2014

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

by Kärkäs, Markus D., Porco, John A., Stephenson, Corey R. J.
Published 2016

Rapid Synthesis of Polyprenylated Acylphloroglucinol Analogs via Dearomative Conjunctive Allylic Annulation

by Grenning, Alexander J., Boyce, Jonathan H., Porco, John A.
Published 2014

Remodeling of the Natural Product Fumagillol Employing a Reaction Discovery Approach

by Balthaser, Bradley R., Maloney, Meghan C., Beeler, Aaron B., Porco, John A., Snyder, John K.
Published 2011

TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN

by Jin, Caining, Rajabi, Hasan, Rodrigo, Christina M., Porco, John A., Kufe, Donald
Published 2012

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

by Leng, Bo, Chichetti, Stephanie, Su, Shun, Beeler, Aaron B, Porco, John A
Published 2012

Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

by Lajkiewicz, Neil J., Cognetta, Armand B., Niphakis, Micah J., Cravatt, Benjamin F., Porco, John A.
Published 2014

Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

by Martin, Véronique I., Goodell, John R., Ingham, Oscar J., Porco, John A., Beeler, Aaron B.
Published 2014

Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines

by Yeo, Alan T., Chennamadhavuni, Spandan, Whitty, Adrian, Porco, John A., Gilmore, Thomas D.
Published 2015

How Proteins Bind Macrocycles

by Villar, Elizabeth A., Beglov, Dmitri, Chennamadhavuni, Spandan, Porco, John A., Kozakov, Dima, Vajda, Sandor, Whitty, Adrian
Published 2014

Thiourea-Catalyzed Enantioselective Addition of Indoles to Pyrones: Alkaloid Cores with Quaternary Carbons

by Yeung, Charles S., Ziegler, Robert E., Porco, John A., Jacobsen, Eric N.
Published 2014

Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products

by Stone, Steven D., Lajkiewicz, Neil J., Whitesell, Luke, Hilmy, Ahmed, Porco, John A.
Published 2014

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

by Liu, Shufeng, Wang, Wenyu, Brown, Lauren E., Qiu, Chao, Lajkiewicz, Neil, Zhao, Ting, Zhou, Jianhua, Porco, John A., Wang, Tony T.
Published 2015

Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities

by ZHU, LIJIA, QI, JI, CHIAO, CHRISTINE YA-CHI, ZHANG, QIANG, PORCO, JOHN A., FALLER, DOUGLAS V., DAI, YAN
Published 2014

Atropselective Syntheses of (−) and (+) Rugulotrosin A Utilizing Point-to-Axial Chirality Transfer

by Qin, Tian, Skraba-Joiner, Sarah L., Khalil, Zeinab G., Johnson, Richard P., Capon, Robert J., Porco, John A.
Published 2015

Fine-tuning of macrophage activation using synthetic rocaglate derivatives

by Bhattacharya, Bidisha, Chatterjee, Sujoy, Devine, William G., Kobzik, Lester, Beeler, Aaron B., Porco, John A., Kramnik, Igor
Published 2016

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

by Schatz, Jonathan H., Oricchio, Elisa, Wolfe, Andrew L., Jiang, Man, Linkov, Irina, Maragulia, Jocelyn, Shi, Weiji, Zhang, Zhigang, Rajasekhar, Vinagolu K., Pagano, Nen C., Porco, John A., Teruya-Feldstein, Julie, Rosen, Neal, Zelenetz, Andrew D., Pelletier, Jerry, Wendel, Hans-Guido
Published 2011

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

by Wolfe, Andrew L., Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K., Sanghvi, Viraj R., Mavrakis, Konstantinos J., Jiang, Man, Roderick, Justine E., Van der Meulen, Joni, Schatz, Jonathan H., Rodrigo, Christina M., Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A., Speleman, Frank, Porco, John A., Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido
Published 2014