Patterns and processes of somatic mutations in nine major cancers

by Jia, Peilin, Pao, William, Zhao, Zhongming
Published 2014

A protein knockdown strategy to study the function of β-catenin in tumorigenesis

by Cong, Feng, Zhang, Jianxuan, Pao, William, Zhou, Pengbo, Varmus, Harold
Published 2003

Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients

by Liu, Lin L., Li, Fei, Pao, William, Michor, Franziska
Published 2015

Consensus Rules in Variant Detection from Next-Generation Sequencing Data

by Jia, Peilin, Li, Fei, Xia, Jufeng, Chen, Haiquan, Ji, Hongbin, Pao, William, Zhao, Zhongming
Published 2012

Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas

by Gong, Yixuan, Somwar, Romel, Politi, Katerina, Balak, Marissa, Chmielecki, Juliann, Jiang, Xuejun, Pao, William
Published 2007

Design of Helical Capacitance Sensor for Holdup Measurement in Two-Phase Stratified Flow: A Sinusoidal Function Approach

by Lim, Lam Ghai, Pao, William K. S., Hamid, Nor Hisham, Tang, Tong Boon
Published 2016

MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis

by Jia, Peilin, Wang, Quan, Chen, Qingxia, Hutchinson, Katherine E, Pao, William, Zhao, Zhongming
Published 2014

Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

by Mumenthaler, Shannon M., Foo, Jasmine, Leder, Kevin, Choi, Nathan C., Agus, David B., Pao, William, Mallick, Parag, Michor, Franziska
Published 2011

Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callers

by Wang, Qingguo, Jia, Peilin, Li, Fei, Chen, Haiquan, Ji, Hongbin, Hucks, Donald, Dahlman, Kimberly Brown, Pao, William, Zhao, Zhongming
Published 2013

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

by Li, Chenguang, Fang, Rong, Sun, Yihua, Han, Xiangkun, Li, Fei, Gao, Bin, Iafrate, A. John, Liu, Xin-Yuan, Pao, William, Chen, Haiquan, Ji, Hongbin
Published 2011

KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

by Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, Zakowski, Maureen F, Heelan, Robert T, Kris, Mark G, Varmus, Harold E
Published 2005

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

by Pao, William, Miller, Vincent A, Politi, Katerina A, Riely, Gregory J, Somwar, Romel, Zakowski, Maureen F, Kris, Mark G, Varmus, Harold
Published 2005

Development of New Mouse Lung Tumor Models Expressing EGFR T790M Mutants Associated with Clinical Resistance to Kinase Inhibitors

by Regales, Lucia, Balak, Marissa N., Gong, Yixuan, Politi, Katerina, Sawai, Ayana, Le, Carl, Koutcher, Jason A., Solit, David B., Rosen, Neal, Zakowski, Maureen F., Pao, William
Published 2007

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

by Mumenthaler, Shannon M, Foo, Jasmine, Choi, Nathan C, Heise, Nicholas, Leder, Kevin, Agus, David B, Pao, William, Michor, Franziska, Mallick, Parag
Published 2015

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma

by Hutchinson, Katherine E., Johnson, Douglas B., Johnson, Adam S., Sanchez, Violeta, Kuba, Maria, Lu, Pengcheng, Chen, Xi, Kelley, Mark C., Wang, Qingguo, Zhao, Zhongming, Kris, Mark, Berger, Michael F., Sosman, Jeffrey A., Pao, William
Published 2015

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

by Chitale, Dhananjay, Gong, Yixuan, Taylor, Barry S., Broderick, Stephen, Brennan, Cameron, Somwar, Romel, Golas, Benjamin, Wang, Lu, Motoi, Noriko, Szoke, Janos, Reinersman, J. Matthew, Major, John, Sander, Chris, Seshan, Venkatraman E., Zakowski, Maureen F., Rusch, Valerie, Pao, William, Gerald, William, Ladanyi, Marc
Published 2009

Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4

by Marks, Jenifer L., McLellan, Michael D., Zakowski, Maureen F., Lash, Alex E., Kasai, Yumi, Broderick, Stephen, Sarkaria, Inderpal S., Pham, DuyKhanh, Singh, Bhuvanesh, Miner, Tracie L., Fewell, Ginger A., Fulton, Lucinda L., Mardis, Elaine R., Wilson, Richard K., Kris, Mark G., Rusch, Valerie W., Varmus, Harold, Pao, William
Published 2007

Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials

by Lovly, Christine M., Dahlman, Kimberly Brown, Fohn, Laurel E., Su, Zengliu, Dias-Santagata, Dora, Hicks, Donna J., Hucks, Donald, Berry, Elizabeth, Terry, Charles, Duke, MarKeesa, Su, Yingjun, Sobolik-Delmaire, Tammy, Richmond, Ann, Kelley, Mark C., Vnencak-Jones, Cindy L., Iafrate, A. John, Sosman, Jeffrey, Pao, William
Published 2012

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

by Galvani, Elena, Sun, Jing, Leon, Leticia G., Sciarrillo, Rocco, Narayan, Ravi S., Tjin Tham Sjin, Robert, Lee, Kwangho, Ohashi, Kadoaki, Heideman, Daniëlle A.M., Alfieri, Roberta R., Heynen, Guus J., Bernards, René, Smit, Egbert F., Pao, William, Peters, Godefridus J., Giovannetti, Elisa
Published 2015

Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone

by Kawabata, Shigeru, Christine Hollander, M, Munasinghe, Jeeva P., Brinster, Lauren R., Mercado-Matos, José R., Li, Jie, Regales, Lucia, Pao, William, Jänne, Pasi A., Wong, Kwok-Kin, Butman, John A., Lonser, Russell R., Hansen, Marlan R., Gurgel, Richard K., Vortmeyer, Alexander O., Dennis, Phillip A.
Published 2015