Pathology is a critical aspect of preclinical aging studies

by Ladiges, Warren, Ikeno, Yuji, Liggitt, Denny, Treuting, Piper M.
Published 2013

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice

by Salmon, Adam B., Flores, Lisa C., Li, Yan, Van Remmen, Holly, Richardson, Arlan, Ikeno, Yuji
Published 2012

Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?

by Ikeno, Yuji, Hubbard, Gene B., Lee, Shuko, Dube, Sara M., Flores, Lisa C., Roman, Madeline G., Bartke, Andrzej
Published 2013

Thioredoxin, oxidative stress, cancer and aging

by Flores, Lisa C, Ortiz, Melanie, Dube, Sara, Hubbard, Gene B, Lee, Shuko, Salmon, Adam, Zhang, Yiqiang, Ikeno, Yuji
Published 2012

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence

by Zhang, Yiqiang, Unnikrishnan, Archana, Deepa, Sathyaseelan S., Liu, Yuhong, Li, Yan, Ikeno, Yuji, Sosnowska, Danuta, Van Remmen, Holly, Richardson, Arlan
Published 2016

The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas

by Mahlke, Megan A., Cortez, Lisa A., Ortiz, Melanie A., Rodriguez, Marisela, Uchida, Koji, Shigenaga, Mark K., Lee, Shuko, Zhang, Yiquang, Tominaga, Kaoru, Hubbard, Gene B., Ikeno, Yuji
Published 2011

Does Reduced IGF-1R Signaling in Igf1r +/− Mice Alter Aging?

by Bokov, Alex F., Garg, Neha, Ikeno, Yuji, Thakur, Sachin, Musi, Nicolas, DeFronzo, Ralph A., Zhang, Ning, Erickson, Rebecca C., Gelfond, Jon, Hubbard, Gene B., Adamo, Martin L., Richardson, Arlan
Published 2011

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

by Livi, Carolina B., Hardman, Rulon L., Christy, Barbara A., Dodds, Sherry G., Jones, Diane, Williams, Charnae, Strong, Randy, Bokov, Alex, Javors, Martin A., Ikeno, Yuji, Hubbard, Gene, Hasty, Paul, Sharp, Zelton Dave
Published 2013

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

by List, Edward O., Berryman, Darlene E., Ikeno, Yuji, Hubbard, Gene B., Funk, Kevin, Comisford, Ross, Young, Jonathan A., Stout, Michael B., Tchkonia, Tamar, Masternak, Michal M., Bartke, Andrzej, Kirkland, James L., Miller, Richard A., Kopchick, John J.
Published 2015

Reductions in serum IGF-1 during aging impair health span

by Gong, Zhenwei, Kennedy, Oran, Sun, Hui, Wu, YingJie, Williams, Garry A, Klein, Laura, Cardoso, Luis, Matheny, Ronald W, Hubbard, Gene B, Ikeno, Yuji, Farrar, Roger P, Schaffler, Mitchell B, Adamo, Martin L, Muzumdar, Radhika H, Yakar, Shoshana
Published 2014

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

by Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C, Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K, Ikeno, Yuji, Hubbard, Gene B, Lenburg, Marc, O’Hara, Steven P, LaRusso, Nicholas F, Miller, Jordan D, Roos, Carolyn M, Verzosa, Grace C, LeBrasseur, Nathan K, Wren, Jonathan D, Farr, Joshua N, Khosla, Sundeep, Stout, Michael B, McGowan, Sara J, Fuhrmann-Stroissnigg, Heike, Gurkar, Aditi U, Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S, Navarro, Diana C, Sano, Tokio, Robbins, Paul D, Niedernhofer, Laura J, Kirkland, James L
Published 2015