Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

by Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Published 2004

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

by Birtwistle, Marc R, Hatakeyama, Mariko, Yumoto, Noriko, Ogunnaike, Babatunde A, Hoek, Jan B, Kholodenko, Boris N
Published 2007

Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades

by Markevich, Nick I, Tsyganov, Mikhail A, Hoek, Jan B, Kholodenko, Boris N
Published 2006

A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration

by Kuttippurathu, Lakshmi, Juskeviciute, Egle, Dippold, Rachael P, Hoek, Jan B., Vadigepalli, Rajanikanth
Published 2016

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy

by Nilakantan, Harshavardhan, Kuttippurathu, Lakshmi, Parrish, Austin, Hoek, Jan B., Vadigepalli, Rajanikanth
Published 2015

A novel, dynamic pattern-based analysis of NF-κB binding during the priming phase of liver regeneration reveals switch-like functional regulation of target genes

by Cook, Daniel J., Patra, Biswanath, Kuttippurathu, Lakshmi, Hoek, Jan B., Vadigepalli, Rajanikanth
Published 2015

Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei

by Freeman, Kate, Brureau, Anthony, Vadigepalli, Rajanikanth, Staehle, Mary M, Brureau, Melanie M, Gonye, Gregory E, Hoek, Jan B, Hooper, D Craig, Schwaber, James S
Published 2012

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

by Birtwistle, Marc R, Rauch, Jens, Kiyatkin, Anatoly, Aksamitiene, Edita, Dobrzyński, Maciej, Hoek, Jan B, Kolch, Walter, Ogunnaike, Babatunde A, Kholodenko, Boris N
Published 2012

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

by Antony, Anil Noronha, Paillard, Melanie, Moffat, Cynthia, Juskeviciute, Egle, Correnti, Jason, Bolon, Brad, Rubin, Emanuel, Csordás, György, Seifert, Erin L., Hoek, Jan B., Hajnóczky, György
Published 2016