Investigating cell death mechanisms in amyotrophic lateral sclerosis using transcriptomics

by Heath, Paul R., Kirby, Janine, Shaw, Pamela J.
Published 2013

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

by Goodall, Emily F., Heath, Paul R., Bandmann, Oliver, Kirby, Janine, Shaw, Pamela J.
Published 2013

Comparison of Blood RNA Extraction Methods Used for Gene Expression Profiling in Amyotrophic Lateral Sclerosis

by Bayatti, Nadhim, Cooper-Knock, Johnathan, Bury, Joanna J., Wyles, Matthew, Heath, Paul R., Kirby, Janine, Shaw, Pamela J.
Published 2014

Luzp4 defines a new mRNA export pathway in cancer cells

by Viphakone, Nicolas, Cumberbatch, Marcus G., Livingstone, Michaela J., Heath, Paul R., Dickman, Mark J., Catto, James W., Wilson, Stuart A.
Published 2015

Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased s...

by Brockington, Alice, Ning, Ke, Heath, Paul R., Wood, Elizabeth, Kirby, Janine, Fusi, Nicolò, Lawrence, Neil, Wharton, Stephen B., Ince, Paul G., Shaw, Pamela J.
Published 2012

The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

by Richardson, Katie, Allen, Scott P., Mortiboys, Heather, Grierson, Andrew J., Wharton, Stephen B., Ince, Paul G., Shaw, Pamela J., Heath, Paul R.
Published 2013

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive...

by Simpson, Julie E., Ince, Paul G., Matthews, Fiona E., Shaw, Pamela J., Heath, Paul R., Brayne, Carol, Garwood, Claire, Higginbottom, Adrian, Wharton, Stephen B.
Published 2015

Immune response in peripheral axons delays disease progression in SOD1G93A mice

by Nardo, Giovanni, Trolese, Maria Chiara, de Vito, Giuseppe, Cecchi, Roberta, Riva, Nilo, Dina, Giorgia, Heath, Paul R., Quattrini, Angelo, Shaw, Pamela J., Piazza, Vincenzo, Bendotti, Caterina
Published 2016

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

by Baker, David J., Blackburn, Daniel J., Keatinge, Marcus, Sokhi, Dilraj, Viskaitis, Paulius, Heath, Paul R., Ferraiuolo, Laura, Kirby, Janine, Shaw, Pamela J.
Published 2015

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

by Cooper-Knock, Johnathan, Bury, Joanna J., Heath, Paul R, Wyles, Matthew, Higginbottom, Adrian, Gelsthorpe, Catherine, Highley, J. Robin, Hautbergue, Guillaume, Rattray, Magnus, Kirby, Janine, Shaw, Pamela J.
Published 2015

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

by Asi, Yasmine T, Simpson, Julie E, Heath, Paul R, Wharton, Stephen B, Lees, Andrew J, Revesz, Tamas, Houlden, Henry, Holton, Janice L
Published 2014

Early Developing Pig Embryos Mediate Their Own Environment in the Maternal Tract

by Almiñana, Carmen, Heath, Paul R., Wilkinson, Stephen, Sanchez-Osorio, Jonatan, Cuello, Cristina, Parrilla, Inmaculada, Gil, Maria A., Vazquez, Jose L., Vazquez, Juan Maria, Roca, Jordi, Martinez, Emilio A., Fazeli, Alireza
Published 2012

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis☆

by Mead, Richard J., Higginbottom, Adrian, Allen, Scott P., Kirby, Janine, Bennett, Ellen, Barber, Siân C., Heath, Paul R., Coluccia, Antonio, Patel, Neelam, Gardner, Iain, Brancale, Andrea, Grierson, Andrew J., Shaw, Pamela J.
Published 2013

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

by Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah V., Simpson, Julie E., Owens, Helen, Vazquez-Villaseñor, Irina, Heath, Paul R., Romero, Ignacio A., Ince, Paul G., Wharton, Stephen B.
Published 2015

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

by Simpson, Julie E., Ince, Paul G., Minett, Thais, Matthews, Fiona E., Heath, Paul R., Shaw, Pamela J., Goodall, Emily, Garwood, Claire J., Ratcliffe, Laura E., Brayne, Carol, Rattray, Magnus, Wharton, Stephen B.
Published 2015

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective...

by Fluteau, Adeline, Ince, Paul G., Minett, Thais, Matthews, Fiona E., Brayne, Carol, Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah, Heath, Paul R., Shaw, Pamela J., Wharton, Stephen B., Simpson, Julie E.
Published 2015

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

by Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver
Published 2014