Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity

by Corzo, Cesar, Griffin, Patrick R.
Published 2013

The therapeutic potential of RORγ modulators in the treatment of human disease

by Chang, Mi Ra, Goswami, Devrishi, Mercer, Becky A, Griffin, Patrick R
Published 2012

Identification of Bexarotene as a PPARγ Antagonist with HDX

by Marciano, David P., Kuruvilla, Dana S., Pascal, Bruce D., Griffin, Patrick R.
Published 2015

Neddylation requires glycyl-tRNA synthetase to protect activated E2

by Mo, Zhongying, Zhang, Qian, Liu, Ze, Lauer, Janelle, Shi, Yi, Sun, Litao, Griffin, Patrick R., Yang, Xiang-Lei
Published 2016

Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

by West, Graham M., Willard, Francis S., Sloop, Kyle W., Showalter, Aaron D., Pascal, Bruce D., Griffin, Patrick R.
Published 2014

Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1

by Lee, Jae Man, Lee, Yoon Kwang, Mamrosh, Jennifer L., Busby, Scott A., Griffin, Patrick R., Pathak, Manish C., Ortlund, Eric A., Moore, David D.
Published 2011

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor

by Yan, Fei, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R., O'Malley, Bert W., Lonard, David M.
Published 2014

Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

by Qiang, Guifen, Xue, Shenghui, Yang, Jenny J., Du, Guanhua, Pang, Xiaobin, Li, Xiaoting, Goswami, Devrishi, Griffin, Patrick R., Ortlund, Eric A., Chan, Chi Bun, Ye, Keqiang
Published 2014

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1

by Heidebrecht, Tatjana, Christodoulou, Evangelos, Chalmers, Michael J., Jan, Sabrina, ter Riet, Bas, Grover, Rajesh K., Joosten, Robbie P., Littler, Dene, van Luenen, Henri, Griffin, Patrick R., Wentworth, Paul, Borst, Piet, Perrakis, Anastassis
Published 2011

An alternate binding site for PPARγ ligands

by Hughes, Travis S., Giri, Pankaj Kumar, de Vera, Ian Mitchelle S., Marciano, David P., Kuruvilla, Dana S., Shin, Youseung, Blayo, Anne-Laure, Kamenecka, Theodore M., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Published 2014

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

by Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M., Shulman, Andrew I., Rance, Mark, Griffin, Patrick R., Bruning, John B., Nettles, Kendall W.
Published 2015

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

by Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L
Published 2016

Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

by Zhang, Hongkai, Sturchler, Emmanuel, Zhu, Jiang, Nieto, Ainhoa, Cistrone, Philip A., Xie, Jia, He, LinLing, Yea, Kyungmoo, Jones, Teresa, Turn, Rachel, Di Stefano, Peter S., Griffin, Patrick R., Dawson, Philip E., McDonald, Patricia H., Lerner, Richard A.
Published 2015

Structural basis of JAZ repression of MYC transcription factors in jasmonate signaling

by Zhang, Feng, Yao, Jian, Ke, Jiyuan, Zhang, Li, Lam, Vinh Q., Xin, Xiu-Fang, Zhou, X. Edward, Chen, Jian, Brunzelle, Joseph, Griffin, Patrick R., Zhou, Mingguo, Xu, H. Eric, Melcher, Karsten, He, Sheng Yang
Published 2015

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

by He, Weiwei, Bai, Ge, Zhou, Huihao, Wei, Na, White, Nicholas M., Lauer, Janelle, Liu, Huaqing, Shi, Yi, Dumitru, Calin Dan, Lettieri, Karen, Shubayev, Veronica, Jordanova, Albena, Guergueltcheva, Velina, Griffin, Patrick R., Burgess, Robert W., Pfaff, Samuel L., Yang, Xiang-Lei
Published 2015

Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

by Solt, Laura A., Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L., Liu, Jin, Istrate, Monica A., Kamenecka, Theodore M., Roush, William R., Vidović, Dušica, Schürer, Stephan C., Xu, Jihong, Wagoner, Gail, Drew, Paul D., Griffin, Patrick R., Burris, Thomas P.
Published 2011

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

by Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Published 2011

Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation

by Choi, Jang Hyun, Banks, Alexander S., Kamenecka, Theodore M., Busby, Scott A., Chalmers, Michael J., Kumar, Naresh, Kuruvilla, Dana S., Shin, Youseung, He, Yuanjun, Bruning, John B., Marciano, David P., Cameron, Michael D., Laznik, Dina, Jurczak, Michael J., Schürer, Stephan C., Vidović, Dušica, Shulman, Gerald I., Spiegelman, Bruce M., Griffin, Patrick R.
Published 2011

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

by Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W
Published 2014

Conformational states of the full-length glucagon receptor

by Yang, Linlin, Yang, Dehua, de Graaf, Chris, Moeller, Arne, West, Graham M., Dharmarajan, Venkatasubramanian, Wang, Chong, Siu, Fai Y., Song, Gaojie, Reedtz-Runge, Steffen, Pascal, Bruce D., Wu, Beili, Potter, Clinton S., Zhou, Hu, Griffin, Patrick R., Carragher, Bridget, Yang, Huaiyu, Wang, Ming-Wei, Stevens, Raymond C., Jiang, Hualiang
Published 2015