DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

The vitamin D receptor (VDR) functions as an obligate heterodimer with the retinoid X receptor (RXR). These nuclear receptors (NRs) are multidomain proteins and it is unclear how various domains interact with one another within the NR heterodimer. Here we show that binding of intact heterodimer to D...

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Bibliographic Details
Main Authors: Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087838/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087838/

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