The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response?

by Garnett, Mathew J, McDermott, Ultan
Published 2014

Targeting the RB-E2F pathway in breast cancer

by Johnson, Jackie, Thijssen, Bram, McDermott, Ultan, Garnett, Mathew, Wessels, Lodewyk F.A., Bernards, René
Published 2016

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

by Menden, Michael P., Iorio, Francesco, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H., Ballester, Pedro J., Saez-Rodriguez, Julio
Published 2013

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

by Knijnenburg, Theo A., Klau, Gunnar W., Iorio, Francesco, Garnett, Mathew J., McDermott, Ultan, Shmulevich, Ilya, Wessels, Lodewyk F. A.
Published 2016

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

by Lynch, James T., McEwen, Robert, Crafter, Claire, McDermott, Ultan, Garnett, Mathew J., Barry, Simon T., Davies, Barry R.
Published 2016

A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions

by Iorio, Francesco, Shrestha, Roshan L., Levin, Nicolas, Boilot, Viviane, Garnett, Mathew J., Saez-Rodriguez, Julio, Draviam, Viji M.
Published 2015

Fast randomization of large genomic datasets while preserving alteration counts

by Gobbi, Andrea, Iorio, Francesco, Dawson, Kevin J., Wedge, David C., Tamborero, David, Alexandrov, Ludmil B., Lopez-Bigas, Nuria, Garnett, Mathew J., Jurman, Giuseppe, Saez-Rodriguez, Julio
Published 2014

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

by Gill, Sonja J., Travers, Jon, Pshenichnaya, Irina, Kogera, Fiona A., Barthorpe, Syd, Mironenko, Tatiana, Richardson, Laura, Benes, Cyril H., Stratton, Michael R., McDermott, Ultan, Jackson, Stephen P., Garnett, Mathew J.
Published 2015

BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib

by Ranzani, Marco, Alifrangis, Constantine, Perna, Daniele, Dutton-Regester, Ken, Pritchard, Antonia, Wong, Kim, Rashid, Mamunur, Robles-Espinoza, Carla Daniela, Hayward, Nicholas K, McDermott, Ultan, Garnett, Mathew, Adams, David J
Published 2015

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

by Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J., Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A., Thompson, I. Richard, Ramaswamy, Sridhar, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Benes, Cyril, McDermott, Ultan, Garnett, Mathew J.
Published 2013

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

by Mardilovich, Katerina, Baugh, Mark, Crighton, Diane, Kowalczyk, Dominika, Gabrielsen, Mads, Munro, June, Croft, Daniel R., Lourenco, Filipe, James, Daniel, Kalna, Gabriella, McGarry, Lynn, Rath, Oliver, Shanks, Emma, Garnett, Mathew J., McDermott, Ultan, Brookfield, Joanna, Charles, Mark, Hammonds, Tim, Olson, Michael F.
Published 2015

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

by Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos
Published 2016

A Landscape of Pharmacogenomic Interactions in Cancer

by Iorio, Francesco, Knijnenburg, Theo A., Vis, Daniel J., Bignell, Graham R., Menden, Michael P., Schubert, Michael, Aben, Nanne, Gonçalves, Emanuel, Barthorpe, Syd, Lightfoot, Howard, Cokelaer, Thomas, Greninger, Patricia, van Dyk, Ewald, Chang, Han, de Silva, Heshani, Heyn, Holger, Deng, Xianming, Egan, Regina K., Liu, Qingsong, Mironenko, Tatiana, Mitropoulos, Xeni, Richardson, Laura, Wang, Jinhua, Zhang, Tinghu, Moran, Sebastian, Sayols, Sergi, Soleimani, Maryam, Tamborero, David, Lopez-Bigas, Nuria, Ross-Macdonald, Petra, Esteller, Manel, Gray, Nathanael S., Haber, Daniel A., Stratton, Michael R., Benes, Cyril H., Wessels, Lodewyk F.A., Saez-Rodriguez, Julio, McDermott, Ultan, Garnett, Mathew J.
Published 2016

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

by Ham, Jungoh, Costa, Carlotta, Sano, Renata, Lochmann, Timothy L., Sennott, Erin M., Patel, Neha U., Dastur, Anahita, Gomez-Caraballo, Maria, Krytska, Kateryna, Hata, Aaron N., Floros, Konstantinos V., Hughes, Mark T., Jakubik, Charles T., Heisey, Daniel A.R., Ferrell, Justin T., Bristol, Molly L., March, Ryan J., Yates, Craig, Hicks, Mark A., Nakajima, Wataru, Gowda, Madhu, Windle, Brad E., Dozmorov, Mikhail G., Garnett, Mathew J., McDermott, Ultan, Harada, Hisashi, Taylor, Shirley M., Morgan, Iain M., Benes, Cyril H., Engelman, Jeffrey A., Mossé, Yael P., Faber, Anthony C.
Published 2016

Systematic identification of genomic markers of drug sensitivity in cancer cells

by Garnett, Mathew J., Edelman, Elena J., Heidorn, Sonja J., Greenman, Chris D., Dastur, Anahita, Lau, King Wai, Greninger, Patricia, Thompson, I. Richard, Luo, Xi, Soares, Jorge, Liu, Qingsong, Iorio, Francesco, Surdez, Didier, Chen, Li, Milano, Randy J., Bignell, Graham R., Tam, Ah T., Davies, Helen, Stevenson, Jesse A., Barthorpe, Syd, Lutz, Stephen R., Kogera, Fiona, Lawrence, Karl, McLaren-Douglas, Anne, Mitropoulos, Xeni, Mironenko, Tatiana, Thi, Helen, Richardson, Laura, Zhou, Wenjun, Jewitt, Frances, Zhang, Tinghu, O’Brien, Patrick, Boisvert, Jessica L., Price, Stacey, Hur, Wooyoung, Yang, Wanjuan, Deng, Xianming, Butler, Adam, Choi, Hwan Geun, Chang, Jae Won, Baselga, Jose, Stamenkovic, Ivan, Engelman, Jeffrey A., Sharma, Sreenath V., Delattre, Olivier, Saez-Rodriguez, Julio, Gray, Nathanael S., Settleman, Jeffrey, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Ramaswamy, Sridhar, McDermott, Ultan, Benes, Cyril H.
Published 2012

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

by Michaut, Magali, Chin, Suet-Feung, Majewski, Ian, Severson, Tesa M., Bismeijer, Tycho, de Koning, Leanne, Peeters, Justine K., Schouten, Philip C., Rueda, Oscar M., Bosma, Astrid J., Tarrant, Finbarr, Fan, Yue, He, Beilei, Xue, Zheng, Mittempergher, Lorenza, Kluin, Roelof J.C., Heijmans, Jeroen, Snel, Mireille, Pereira, Bernard, Schlicker, Andreas, Provenzano, Elena, Ali, Hamid Raza, Gaber, Alexander, O’Hurley, Gillian, Lehn, Sophie, Muris, Jettie J.F., Wesseling, Jelle, Kay, Elaine, Sammut, Stephen John, Bardwell, Helen A., Barbet, Aurélie S., Bard, Floriane, Lecerf, Caroline, O’Connor, Darran P., Vis, Daniël J., Benes, Cyril H., McDermott, Ultan, Garnett, Mathew J., Simon, Iris M., Jirström, Karin, Dubois, Thierry, Linn, Sabine C., Gallagher, William M., Wessels, Lodewyk F.A., Caldas, Carlos, Bernards, Rene
Published 2016

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

by Secrier, Maria, Li, Xiaodun, de Silva, Nadeera, Eldridge, Matthew D., Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Núria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P., Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A.W., Lynch, Andy G., Tavaré, Simon, Fitzgerald, Rebecca C., Noorani, Ayesha, Elliott, Rachael Fels, Weaver, Jamie, Ross-Innes, Caryn, Smith, Laura, Abdullahi, Zarah, de la Rue, Rachel, Cluroe, Alison, Malhotra, Shalini, Hardwick, Richard, Ford, Hugo, Smith, Mike L., Davies, Jim, Turkington, Richard, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O'Neill, J. Robert, Tucker, Olga, Taniere, Philippe, Noble, Fergus, Owsley, Jack, Lovat, Laurence, Haidry, Rehan, Eneh, Victor, Crichton, Charles, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Sanders, Grant, Berrisford, Richard, Harden, Catherine, Bunting, David, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Collier, Pamela, Igali, Laszlo, Welch, Ian, Scott, Michael, Sothi, Shamila, Suortamo, Sari, Lishman, Suzy, Beardsmore, Duncan, Francies, Hayley E., Garnett, Mathew J., Pearson, John V., Nones, Katia, Patch, Ann-Marie, Grimmond, Sean M.
Published 2016