Innate Immune Sensing of DNA

by Sharma, Shruti, Fitzgerald, Katherine A.
Published 2011

Resistance to HSV-1 Infection in the Epithelium Resides with the Novel Innate Sensor, IFI-16

by Conrady, Christopher D., Zheng, Min, Fitzgerald, Katherine A., Liu, Chuanju, Carr, Daniel J.J.
Published 2012

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

by Thompson, Mikayla R., Kaminski, John J., Kurt-Jones, Evelyn A., Fitzgerald, Katherine A.
Published 2011

Defective pro-IL-1β responses in macrophages from aged mice

by Ramirez, Alejandro, Rathinam, Vijay, Fitzgerald, Katherine A, Golenbock, Douglas T, Mathew, Anuja
Published 2012

AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

by Hornung, Veit, Ablasser, Andrea, Charrel-Dennis, Marie, Bauernfeind, Franz, Horvath, Gabor, Caffrey, Daniel R., Latz, Eicke, Fitzgerald, Katherine A.
Published 2009

A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans

by Tomalka, Jeffrey, Ganesan, Sandhya, Azodi, Elaheh, Patel, Krupen, Majmudar, Parth, Hall, Brian A., Fitzgerald, Katherine A., Hise, Amy G.
Published 2011

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

by Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, Monks, Brian, Pitha, Paula M., Golenbock, Douglas T.
Published 2003

Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

by Stack, Julianne, Haga, Ismar R., Schröder, Martina, Bartlett, Nathan W., Maloney, Geraldine, Reading, Patrick C., Fitzgerald, Katherine A., Smith, Geoffrey L., Bowie, Andrew G.
Published 2005

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract

by Parker, Dane, Martin, Francis J., Soong, Grace, Harfenist, Bryan S., Aguilar, Jorge L., Ratner, Adam J., Fitzgerald, Katherine A., Schindler, Christian, Prince, Alice
Published 2011

Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release

by Nakahira, Kiichi, Haspel, Jeffrey Adam, Rathinam, Vijay AK, Lee, Seon-Jin, Dolinay, Tamas, Lam, Hilaire C, Englert, Joshua A, Rabinovitch, Marlene, Cernadas, Manuela, Kim, Hong Pyo, Fitzgerald, Katherine A, Ryter, Stefan W, Choi, Augustine MK
Published 2010

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

by Roberts, Zachary J., Goutagny, Nadege, Perera, Pin-Yu, Kato, Hiroki, Kumar, Himanshu, Kawai, Taro, Akira, Shizuo, Savan, Ram, van Echo, David, Fitzgerald, Katherine A., Young, Howard A., Ching, Lai-Ming, Vogel, Stefanie N.
Published 2007

CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

by Sheedy, Frederick J., Grebe, Alena, Rayner, Katey J., Kalantari, Parisa, Ramkhelawon, Bhama, Carpenter, Susan B., Becker, Christine E., Ediriweera, Hasini N., Mullick, Adam E., Golenbock, Douglas T., Stuart, Lynda M., Latz, Eicke, Fitzgerald, Katherine A., Moore, Kathryn J.
Published 2013

IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

by Kim, Hye Young, Lee, Hyun Jun, Chang, Ya-Jen, Pichavant, Muriel, Shore, Stephanie A., Fitzgerald, Katherine A., Iwakura, Yoichiro, Israel, Elliot, Bolger, Kenneth, Faul, John, DeKruyff, Rosemarie H., Umetsu, Dale T.
Published 2013

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

by Ataide, Marco A., Andrade, Warrison A., Zamboni, Dario S., Wang, Donghai, Souza, Maria do Carmo, Franklin, Bernardo S., Elian, Samir, Martins, Flaviano S., Pereira, Dhelio, Reed, George, Fitzgerald, Katherine A., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Published 2014

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

by Sokolovska, Anna, Becker, Christine E., Eddie Ip, WK, Rathinam, Vijay A.K., Brudner, Matthew, Paquette, Nicholas, Tanne, Antoine, Vanaja, Sivapriya K., Moore, Kathryn J., Fitzgerald, Katherine A., Lacy-Hulbert, Adam, Stuart, Lynda M.
Published 2013

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

by Reinert, Line S., Lopušná, Katarína, Winther, Henriette, Sun, Chenglong, Thomsen, Martin K., Nandakumar, Ramya, Mogensen, Trine H., Meyer, Morten, Vægter, Christian, Nyengaard, Jens R., Fitzgerald, Katherine A., Paludan, Søren R.
Published 2016

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

by Kang, Seokwon, Fernandes-Alnemri, Teresa, Rogers, Corey, Mayes, Lindsey, Wang, Ying, Dillon, Christopher, Roback, Linda, Kaiser, William, Oberst, Andrew, Sagara, Junji, Fitzgerald, Katherine A., Green, Douglas R., Zhang, Jianke, Mocarski, Edward S., Alnemri, Emad S.
Published 2015

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

by Holm, Christian K, Jensen, Søren B, Jakobsen, Martin R, Cheshenko, Natalia, Horan, Kristy A, Moeller, Hanne B, Gonzalez-Dosal, Regina, Rasmussen, Simon B, Christensen, Maria H., Yarovinsky, Timur O, Rixon, Frazer J, Herold, Betsy C, Fitzgerald, Katherine A, Paludan, Søren R
Published 2012

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

by Holm, Christian K., Rahbek, Stine H., Gad, Hans Henrik, Bak, Rasmus O., Jakobsen, Martin R., Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K., Sun, Chenglong, Thomsen, Martin K., Laustsen, Anders, Nielsen, Camilla G., Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L., Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A., Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, Paludan, Søren R.
Published 2016

IKKα negatively regulates ASC-dependent inflammasome activation

by Martin, Bradley N., Wang, Chenhui, Willette-Brown, Jami, Herjan, Tomasz, Gulen, Muhammet F., Zhou, Hao, Bulek, Katarzyna, Franchi, Luigi, Sato, Takashi, Narla, Goutham, Zhong, Xiao-Ping, Thomas, James, Klinman, Dennis, Fitzgerald, Katherine A., Karin, Michael, Nuñez, Gabriel, Dubyak, George, Hu, Yinling, Li, Xiaoxia
Published 2014