Gerosuppressant Metformin: less is more

by Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Vellon, Luciano, Joven, Jorge, Vazquez-Martin, Alejandro
Published 2011

Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: New insight into the role of mitophagy in cell stemness

by Vazquez-Martin, Alejandro, Cufí, Sílvia, Corominas-Faja, Bruna, Oliveras-Ferraros, Cristina, Vellon, Luciano, Menendez, Javier A.
Published 2012

Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer

by Relat, Joana, Blancafort, Adriana, Oliveras, Glòria, Cufí, Sílvia, Haro, Diego, Marrero, Pedro F, Puig, Teresa
Published 2012

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

by Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Joven, Jorge, Vellon, Luciano, Vazquez-Martin, Alejandro
Published 2011

Circulating fatty acid synthase: an exploratory biomarker to predict efficacy of the dual HER1/HER2 tyrosine kinase inhibitor lapatinib

by Oliveras-Ferraros, Cristina, Cufí, Sílvia, Sauri-Nadal, Tamara, Barco, Sonia Del, Martin-Castillo, Begoña, Vazquez-Martin, Alejandro, Menendez, Javier A
Published 2011

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide b...

by Cufí, Sílvia, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Urruticoechea, Ander, Martin-Castillo, Begoña, Menendez, Javier A.
Published 2012

Metformin limits the tumourigenicity of iPS cells without affecting their pluripotency

by Vazquez-Martin, Alejandro, Cufi, Sílvia, Lopez-Bonet, Eugeni, Corominas-Faja, Bruna, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Menendez, Javier A.
Published 2012

Metformin: Multi-faceted protection against cancer

by Del Barco, Sonia, Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Bosch-Barrera, Joaquim, Joven, Jorge, Martin-Castillo, Begoña, Menendez, Javier A.
Published 2011

Metformin-induced preferential killing of breast cancer initiating CD44+CD24−/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xen...

by Cufí, Sílvia, Corominas-Faja, Bruna, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Dorca, Joan, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, Menendez, Javier A.
Published 2012

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

by Puig, Teresa, Aguilar, Helena, Cufí, Sílvia, Oliveras, Glòria, Turrado, Carlos, Ortega-Gutiérrez, Sílvia, Benhamú, Bellinda, López-Rodríguez, María Luz, Urruticoechea, Ander, Colomer, Ramon
Published 2011

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

by Corominas-Faja, Bruna, Quirantes-Piné, Rosa, Oliveras-Ferraros, Cristina, Vazquez-Martin, Alejandro, Cufí, Sílvia, Martin-Castillo, Begoña, Micol, Vicente, Joven, Jorge, Segura-Carretero, Antonio, Menendez, Javier A.
Published 2012

The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

by Cufí, Sílvia, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cuyàs, Elisabet, López-Bonet, Eugeni, Martin-Castillo, Begoña, Joven, Jorge, Menendez, Javier A.
Published 2013

Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin

by Manuel Iglesias, Juan, Beloqui, Izaskun, Garcia-Garcia, Francisco, Leis, Olatz, Vazquez-Martin, Alejandro, Eguiara, Arrate, Cufi, Silvia, Pavon, Andres, Menendez, Javier A., Dopazo, Joaquin, Martin, Angel G.
Published 2013

Oncobiguanides: Paracelsus' law and nonconventional routes for administering diabetobiguanides for cancer treatment

by Menendez, Javier A., Quirantes-Piné, Rosa, Rodríguez-Gallego, Esther, Cufí, Sílvia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, Segura-Carretero, Antonio, Joven, Jorge
Published 2014

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

by Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Torres-Garcia, Violeta Zenobia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Bonavia, Rosa, Visa, Joana, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A.
Published 2013

Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

by Cufí, Sílvia, Bonavia, Rosa, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cuyàs, Elisabet, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Visa, Joana, Segura-Carretero, Antonio, Joven, Jorge, Bosch-Barrera, Joaquim, Micol, Vicente, Menendez, Javier A.
Published 2013

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

by Vazquez-Martin, Alejandro, Van den Haute, Chris, Cufí, Sílvia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Lopez-Bonet, Eugeni, Rodriguez-Gallego, Esther, Fernández-Arroyo, Salvador, Joven, Jorge, Baekelandt, Veerle, Menendez, Javier A.
Published 2016

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin

by Cufí, Sílvia, Corominas-Faja, Bruna, Lopez-Bonet, Eugeni, Bonavia, Rosa, Pernas, Sonia, López, Isabel álvarez, Dorca, Joan, Martínez, Susana, López, Norberto Batista, Fernández, Severina Domínguez, Cuyàs, Elisabet, Visa, Joana, Rodríguez-Gallego, Esther, Quirantes-Piné, Rosa, Segura-Carretero, Antonio, Joven, Jorge, Martin-Castillo, Begoña, Menendez, Javier A.
Published 2013

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics

by Puig-Costa, Manuel, Codina-Cazador, Antonio, Cortés-Pastoret, Elisabet, Oliveras-Ferraros, Cristina, Cufí, Sílvia, Flaquer, Sílvia, Llopis-Puigmarti, Francesca, Pujol-Amado, Eulalia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Ortiz, Rosa, Lopez-Bonet, Eugeni, Queralt, Bernardo, Guardeño, Raquel, Martin-Castillo, Begoña, Roig, Josep, Joven, Jorge, Menendez, Javier A.
Published 2014