MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling

by Evans, Catherine, Cook, Simon J., Coleman, Michael P., Gilley, Jonathan
Published 2013

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

by Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Published 2014

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a

by Carragher, Linda A S, Snell, Kimberley R, Giblett, Susan M, Aldridge, Victoria S S, Patel, Bipin, Cook, Simon J, Winton, Doug J, Marais, Richard, Pritchard, Catrin A
Published 2010

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation

by Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.
Published 2016

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

by Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Published 2015

Maternal DNA Methylation Regulates Early Trophoblast Development

by Branco, Miguel R., King, Michelle, Perez-Garcia, Vicente, Bogutz, Aaron B., Caley, Matthew, Fineberg, Elena, Lefebvre, Louis, Cook, Simon J., Dean, Wendy, Hemberger, Myriam, Reik, Wolf
Published 2016

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

by Ficz, Gabriella, Hore, Timothy A., Santos, Fátima, Lee, Heather J., Dean, Wendy, Arand, Julia, Krueger, Felix, Oxley, David, Paul, Yu-Lee, Walter, Jörn, Cook, Simon J., Andrews, Simon, Branco, Miguel R., Reik, Wolf
Published 2013

FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

by Ficz, Gabriella, Hore, Timothy A, Santos, Fatima, Lee, Heather J, Dean, Wendy, Arand, Julia, Krueger, Felix, Oxley, David, Paul, Yu-Lee, Walter, Jörn, Cook, Simon J, Andrews, Simon, Branco, Miguel R, Reik, Wolf
Published 2013

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

by Ashford, Anne L., Dunkley, Tom P. J., Cockerill, Mark, Rowlinson, Rachel A., Baak, Lisa M., Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M., Ward, Richard A., Lochhead, Pamela A., Guichard, Sylvie, Hudson, Kevin, Cook, Simon J.
Published 2015