Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription facto...

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Bibliographic Details
Main Authors: Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263130/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263130/

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