Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor
A partial glucose biosensor was constructed using a selective internal layer, an enzyme layer and a gold electrode. Both membrane layers are based on cross-linked polyvinyl alcohol (PVA). The performance of the partial glucose biosensor was analyzed particularly with respect to the interfering effec...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit UTM Press
2009
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/9996/ http://eprints.utm.my/9996/1/UTMjurnalTEK_51F_DIS%5B08%5D.pdf |
| _version_ | 1848891991983652864 |
|---|---|
| author | Abd. Aziz, Azila |
| author_facet | Abd. Aziz, Azila |
| author_sort | Abd. Aziz, Azila |
| building | UTeM Institutional Repository |
| collection | Online Access |
| description | A partial glucose biosensor was constructed using a selective internal layer, an enzyme layer and a gold electrode. Both membrane layers are based on cross-linked polyvinyl alcohol (PVA). The performance of the partial glucose biosensor was analyzed particularly with respect to the interfering effects of acetaminophen, a non-ionic molecule. The sensitivity of the immobilized enzyme to glucose was high but it was not high enough to counter acetaminophen interference. The addition of the moderately selective PVA internal layer did not seem to have a significant effect on interference. A mathematical model was then used to analyze the performance of a completed biosensor. A simulated external layer was added to the two layers. The mathematical model predicted that the addition of an external layer with lowered permeability to solutes could improve the performance of the sensor. |
| first_indexed | 2025-11-15T21:06:46Z |
| format | Article |
| id | utm-9996 |
| institution | Universiti Teknologi Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T21:06:46Z |
| publishDate | 2009 |
| publisher | Penerbit UTM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utm-99962010-07-22T02:03:27Z http://eprints.utm.my/9996/ Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor Abd. Aziz, Azila TP Chemical technology A partial glucose biosensor was constructed using a selective internal layer, an enzyme layer and a gold electrode. Both membrane layers are based on cross-linked polyvinyl alcohol (PVA). The performance of the partial glucose biosensor was analyzed particularly with respect to the interfering effects of acetaminophen, a non-ionic molecule. The sensitivity of the immobilized enzyme to glucose was high but it was not high enough to counter acetaminophen interference. The addition of the moderately selective PVA internal layer did not seem to have a significant effect on interference. A mathematical model was then used to analyze the performance of a completed biosensor. A simulated external layer was added to the two layers. The mathematical model predicted that the addition of an external layer with lowered permeability to solutes could improve the performance of the sensor. Penerbit UTM Press 2009-12 Article PeerReviewed application/pdf en http://eprints.utm.my/9996/1/UTMjurnalTEK_51F_DIS%5B08%5D.pdf Abd. Aziz, Azila (2009) Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor. Jurnal Teknologi (Kejuruteraan) (51F). pp. 96-106. ISSN 0127-9696 http://www.penerbit.utm.my/onlinejournal/51/F/51sirif08.pdf |
| spellingShingle | TP Chemical technology Abd. Aziz, Azila Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title | Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title_full | Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title_fullStr | Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title_full_unstemmed | Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title_short | Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| title_sort | quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/9996/ http://eprints.utm.my/9996/ http://eprints.utm.my/9996/1/UTMjurnalTEK_51F_DIS%5B08%5D.pdf |