The role of monocytic microparticles (mMP) in endothelial cell function
Monocytic microparticles (mMP) are membrane-derived microvesicles released from activated or apoptotic monocytes. Monocytic MP are associated with inflammation and may play important role in endothelial cell function. The main aim of this study was to identify phenotypic profiles of mMP derived f...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2019
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| Online Access: | http://eprints.usm.my/51980/ http://eprints.usm.my/51980/1/Maryam%20Azlan-Eprints.pdf |
| _version_ | 1848882134114107392 |
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| author | Azlan, Maryam |
| author_facet | Azlan, Maryam |
| author_sort | Azlan, Maryam |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Monocytic microparticles (mMP) are membrane-derived microvesicles released from activated or
apoptotic monocytes. Monocytic MP are associated with inflammation and may play important
role in endothelial cell function. The main aim of this study was to identify phenotypic profiles of
mMP derived from THP-1, unseparated monocytes, co14• monocytes and CD1 a• monocytes by
flow cytometry and to identify the role of mMP in endothelial cell activation. Monocytic MP derived
from unseparated monocytes, co14• monocytes and CD1a+ monocytes but not THP-1 showed
high expression of CD14 and CD16, secreted IL-113 and TNF-a and activated endothelial cells.
Taken together our findings suggest that mMP derived from different cell types exhibit different
phenotypes and functions. Future study of mMP is necessary to understand their mechanism of
action. |
| first_indexed | 2025-11-15T18:30:05Z |
| format | Article |
| id | usm-51980 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:30:05Z |
| publishDate | 2019 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-519802022-03-20T01:57:56Z http://eprints.usm.my/51980/ The role of monocytic microparticles (mMP) in endothelial cell function Azlan, Maryam R Medicine Monocytic microparticles (mMP) are membrane-derived microvesicles released from activated or apoptotic monocytes. Monocytic MP are associated with inflammation and may play important role in endothelial cell function. The main aim of this study was to identify phenotypic profiles of mMP derived from THP-1, unseparated monocytes, co14• monocytes and CD1 a• monocytes by flow cytometry and to identify the role of mMP in endothelial cell activation. Monocytic MP derived from unseparated monocytes, co14• monocytes and CD1a+ monocytes but not THP-1 showed high expression of CD14 and CD16, secreted IL-113 and TNF-a and activated endothelial cells. Taken together our findings suggest that mMP derived from different cell types exhibit different phenotypes and functions. Future study of mMP is necessary to understand their mechanism of action. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019 Article NonPeerReviewed application/pdf en http://eprints.usm.my/51980/1/Maryam%20Azlan-Eprints.pdf Azlan, Maryam (2019) The role of monocytic microparticles (mMP) in endothelial cell function. The role of monocytic microparticles (mMP) in endothelial cell function. |
| spellingShingle | R Medicine Azlan, Maryam The role of monocytic microparticles (mMP) in endothelial cell function |
| title | The role of monocytic microparticles (mMP) in endothelial
cell function |
| title_full | The role of monocytic microparticles (mMP) in endothelial
cell function |
| title_fullStr | The role of monocytic microparticles (mMP) in endothelial
cell function |
| title_full_unstemmed | The role of monocytic microparticles (mMP) in endothelial
cell function |
| title_short | The role of monocytic microparticles (mMP) in endothelial
cell function |
| title_sort | role of monocytic microparticles (mmp) in endothelial
cell function |
| topic | R Medicine |
| url | http://eprints.usm.my/51980/ http://eprints.usm.my/51980/1/Maryam%20Azlan-Eprints.pdf |