Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were scr...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | http://eprints.usm.my/46191/ http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf |
| _version_ | 1848880539163951104 |
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| author | Mohammed, Omar Saeed Ali |
| author_facet | Mohammed, Omar Saeed Ali |
| author_sort | Mohammed, Omar Saeed Ali |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. |
| first_indexed | 2025-11-15T18:04:44Z |
| format | Thesis |
| id | usm-46191 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:04:44Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-461912020-02-12T07:59:31Z http://eprints.usm.my/46191/ Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia Mohammed, Omar Saeed Ali RK1-715 Dentistry The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. 2013-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf Mohammed, Omar Saeed Ali (2013) Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RK1-715 Dentistry Mohammed, Omar Saeed Ali Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_fullStr | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full_unstemmed | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_short | Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_sort | anti-neoplastic studies of standardized root extract of eurycomal longifolia (taf273) towards leukaemia |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/46191/ http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf |