Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System
The aim of this study was to optimise the experimental conditions for the synthesis of silica nanoparticles. In achieving this, the amount of butanol, the amount of surfactant, the amount of silica precursor, the synthesis temperature and the agitation speed were optimised by applying the Taguchi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor's University
2015
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| Online Access: | http://eprints.usm.my/42781/ http://eprints.usm.my/42781/1/JES_Vol._11_2015_-_Art._2%289-16%29.pdf |
| _version_ | 1848879654635569152 |
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| author | Zainal, Nor Ain Shukor, Syamsul Rizal Abd. Razak, Khairunisak Abdul |
| author_facet | Zainal, Nor Ain Shukor, Syamsul Rizal Abd. Razak, Khairunisak Abdul |
| author_sort | Zainal, Nor Ain |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The aim of this study was to optimise the experimental conditions for the
synthesis of silica nanoparticles. In achieving this, the amount of butanol, the amount of
surfactant, the amount of silica precursor, the synthesis temperature and the agitation
speed were optimised by applying the Taguchi orthogonal arrays method. The optimal
synthesis conditions for silica nanoparticle production were a temperature of 50°C, 6 ml
butanol, 7 ml Tween 80, 3 ml trimethoxyvinylsilane (TMVS), and an agitation speed of
320 rpm. The nanoparticle size was characterised to optimise the synthesis conditions
and determined to be smaller than 100 nm using a Malvern Zetasizer Nano ZS and a
transmission electron microscope (TEM). |
| first_indexed | 2025-11-15T17:50:40Z |
| format | Article |
| id | usm-42781 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:50:40Z |
| publishDate | 2015 |
| publisher | Taylor's University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-427812018-10-30T01:27:29Z http://eprints.usm.my/42781/ Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System Zainal, Nor Ain Shukor, Syamsul Rizal Abd. Razak, Khairunisak Abdul TA1-2040 Engineering (General). Civil engineering (General) The aim of this study was to optimise the experimental conditions for the synthesis of silica nanoparticles. In achieving this, the amount of butanol, the amount of surfactant, the amount of silica precursor, the synthesis temperature and the agitation speed were optimised by applying the Taguchi orthogonal arrays method. The optimal synthesis conditions for silica nanoparticle production were a temperature of 50°C, 6 ml butanol, 7 ml Tween 80, 3 ml trimethoxyvinylsilane (TMVS), and an agitation speed of 320 rpm. The nanoparticle size was characterised to optimise the synthesis conditions and determined to be smaller than 100 nm using a Malvern Zetasizer Nano ZS and a transmission electron microscope (TEM). Taylor's University 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/42781/1/JES_Vol._11_2015_-_Art._2%289-16%29.pdf Zainal, Nor Ain and Shukor, Syamsul Rizal Abd. and Razak, Khairunisak Abdul (2015) Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System. Journal of Engineering Science and Technology, 11. pp. 9-16. ISSN 1823-4690 http://web.usm.my/jes/11_2015/JES%20Vol.%2011%202015%20-%20Art.%202(9-16).pdf |
| spellingShingle | TA1-2040 Engineering (General). Civil engineering (General) Zainal, Nor Ain Shukor, Syamsul Rizal Abd. Razak, Khairunisak Abdul Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title | Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title_full | Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title_fullStr | Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title_full_unstemmed | Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title_short | Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System |
| title_sort | applying the taguchi method to optimise the size of silica nanoparticles entrapped with rifampicin for a drug delivery system |
| topic | TA1-2040 Engineering (General). Civil engineering (General) |
| url | http://eprints.usm.my/42781/ http://eprints.usm.my/42781/ http://eprints.usm.my/42781/1/JES_Vol._11_2015_-_Art._2%289-16%29.pdf |