Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?

Latar belakang: Plasma sejuk segar (fresh frozen plasma; FFP) ialah komponen darah yang sering dipohon oleh doktor sama ada bertujuan untuk transfusi terapeutik atau transfusi profilaktik. Transfusi profilaktik FFP di kalangan pesakit yang mempunyai masalah pembekuan darah (coagulopathy) adalah u...

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Main Author:	Mohamad Mahyedin, Mohd Tarmizi
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/40604/ http://eprints.usm.my/40604/1/MOHD_TARMIZI_BIN_MOHAMAD_MAHYEDIN.pdf

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author	Mohamad Mahyedin, Mohd Tarmizi
author_facet	Mohamad Mahyedin, Mohd Tarmizi
author_sort	Mohamad Mahyedin, Mohd Tarmizi
building	USM Institutional Repository
collection	Online Access
description	Latar belakang: Plasma sejuk segar (fresh frozen plasma; FFP) ialah komponen darah yang sering dipohon oleh doktor sama ada bertujuan untuk transfusi terapeutik atau transfusi profilaktik. Transfusi profilaktik FFP di kalangan pesakit yang mempunyai masalah pembekuan darah (coagulopathy) adalah untuk mengelakkan episod pendarahan ketika prosedur rawatan invasif. Nilai international normalised ratio (INR) melebihi 1.50 sering dijadikan nilai penanda bagi transfusi FFP sebelum prosedur intervensi. Kajian ini berhasrat untuk menilai keberkesanan transfusi FFP dalam menormalkan bacaan INR sebelum prosedur intervensi dijalankan dan menentukan hasil transfusi ini (perbezaan INR, episod pendarahan dan reaksi tindakbalas transfusi). Kaedah: Kajian prospectif keratan rentas dijalankan dengan data daripada 81 pesakit yang menerima transfusi FFP sebelum prosedur intervensi selama tempoh tiga bulan (Disember 2016 hingga Febuari 2017). Kajian ini telah dijalankan di Hospital Kuala Lumpur dan Pusat Darah Negara. Subjek kajian ini dipilih secara persampelan khusus di mana setiap pesakit yang merekodkan bacaan INR melebihi 1.50 dipilih. Data diperoleh daripada rekod perubatan pesakit dan diisi dalam proforma kajian. Kesemua data demografik dan klinikal berkaitan dengan keberkesanan transfusi FFP dicatatkan dan kemudiannya dianalisa. Background: The fresh frozen plasma (FFP) is frequently prescribed by the clinicians either for therapeutic or prophylactic purpose. Prophylactic FFP transfusion in coagulopathic patient is given to prevent any bleeding complications during invasive procedures. The international normalised ratio (INR) value of 1.50 and above is frequently reported to be a transfusion trigger for FFP prior to interventional procedure. This study aims to evaluate the efficacy of FFP transfusion in normalising the INR prior to interventional procedures. On top of that, it is also to determine the post-transfusion outcomes (INR difference, bleeding episodes and adverse transfusion reactions). Methods: A prospective cross-sectional study involved 81 patients who received prophylactic FFP transfusion prior to interventional procedures over a period of three months (December 2016 until February 2017). The study was conducted at both Hospital Kuala Lumpur and Pusat Darah Negara. Study subjects with abnormal coagulation laboratory value (pretransfusion INR above 1.50) were selected by purposive (nonprobability) sampling. Data retrieved from patient’s medical record and were filled in the research proforma. All demographic and clinical data in regards to the outcome of FFP transfusion were captured
first_indexed	2025-11-15T17:41:21Z
format	Thesis
id	usm-40604
institution	Universiti Sains Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T17:41:21Z
publishDate	2017
recordtype	eprints
repository_type	Digital Repository
spelling	usm-406042019-04-12T05:25:07Z http://eprints.usm.my/40604/ Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary? Mohamad Mahyedin, Mohd Tarmizi RK1-715 Dentistry Latar belakang: Plasma sejuk segar (fresh frozen plasma; FFP) ialah komponen darah yang sering dipohon oleh doktor sama ada bertujuan untuk transfusi terapeutik atau transfusi profilaktik. Transfusi profilaktik FFP di kalangan pesakit yang mempunyai masalah pembekuan darah (coagulopathy) adalah untuk mengelakkan episod pendarahan ketika prosedur rawatan invasif. Nilai international normalised ratio (INR) melebihi 1.50 sering dijadikan nilai penanda bagi transfusi FFP sebelum prosedur intervensi. Kajian ini berhasrat untuk menilai keberkesanan transfusi FFP dalam menormalkan bacaan INR sebelum prosedur intervensi dijalankan dan menentukan hasil transfusi ini (perbezaan INR, episod pendarahan dan reaksi tindakbalas transfusi). Kaedah: Kajian prospectif keratan rentas dijalankan dengan data daripada 81 pesakit yang menerima transfusi FFP sebelum prosedur intervensi selama tempoh tiga bulan (Disember 2016 hingga Febuari 2017). Kajian ini telah dijalankan di Hospital Kuala Lumpur dan Pusat Darah Negara. Subjek kajian ini dipilih secara persampelan khusus di mana setiap pesakit yang merekodkan bacaan INR melebihi 1.50 dipilih. Data diperoleh daripada rekod perubatan pesakit dan diisi dalam proforma kajian. Kesemua data demografik dan klinikal berkaitan dengan keberkesanan transfusi FFP dicatatkan dan kemudiannya dianalisa. Background: The fresh frozen plasma (FFP) is frequently prescribed by the clinicians either for therapeutic or prophylactic purpose. Prophylactic FFP transfusion in coagulopathic patient is given to prevent any bleeding complications during invasive procedures. The international normalised ratio (INR) value of 1.50 and above is frequently reported to be a transfusion trigger for FFP prior to interventional procedure. This study aims to evaluate the efficacy of FFP transfusion in normalising the INR prior to interventional procedures. On top of that, it is also to determine the post-transfusion outcomes (INR difference, bleeding episodes and adverse transfusion reactions). Methods: A prospective cross-sectional study involved 81 patients who received prophylactic FFP transfusion prior to interventional procedures over a period of three months (December 2016 until February 2017). The study was conducted at both Hospital Kuala Lumpur and Pusat Darah Negara. Study subjects with abnormal coagulation laboratory value (pretransfusion INR above 1.50) were selected by purposive (nonprobability) sampling. Data retrieved from patient’s medical record and were filled in the research proforma. All demographic and clinical data in regards to the outcome of FFP transfusion were captured 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/40604/1/MOHD_TARMIZI_BIN_MOHAMAD_MAHYEDIN.pdf Mohamad Mahyedin, Mohd Tarmizi (2017) Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary? Masters thesis, Universiti Sains Malaysia.
spellingShingle	RK1-715 Dentistry Mohamad Mahyedin, Mohd Tarmizi Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title	Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title_full	Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title_fullStr	Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title_full_unstemmed	Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title_short	Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?
title_sort	normalisation of the international normalised ratio prior to interventional procedure: is it necessary?
topic	RK1-715 Dentistry
url	http://eprints.usm.my/40604/ http://eprints.usm.my/40604/1/MOHD_TARMIZI_BIN_MOHAMAD_MAHYEDIN.pdf

Normalisation Of The International Normalised Ratio Prior To Interventional Procedure: Is It Necessary?

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