Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Akademie Ved Ceske Republiky
2017
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| Online Access: | http://eprints.usm.my/38100/ http://eprints.usm.my/38100/1/Lipopolysaccharides_induced_memory_impairment.pdf |
| _version_ | 1848878373030330368 |
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| author | R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi |
| author_facet | R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi |
| author_sort | R., Zakaria |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Alzheimer’s disease (AD) is a primary cause of dementia in the
middle-aged and elderly worldwide. Animal models for AD are
widely used to study the disease mechanisms as well as to test
potential therapeutic agents for disease modification. Among the
non-genetically manipulated neuroinflammation models for AD,
lipopolysaccharide (LPS)-induced animal model is commonly
used. This review paper aims to discuss the possible factors that
influence rats’ response following LPS injection. Factors such as
dose of LPS, route of administration, nature and duration of
exposure as well as age and gender of animal used should be
taken into account when designing a study using LPS-induced
memory impairment as model for AD. |
| first_indexed | 2025-11-15T17:30:18Z |
| format | Article |
| id | usm-38100 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:30:18Z |
| publishDate | 2017 |
| publisher | Akademie Ved Ceske Republiky |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-381002017-12-27T04:03:52Z http://eprints.usm.my/38100/ Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi RC31-1245 Internal medicine Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD. Akademie Ved Ceske Republiky 2017 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/38100/1/Lipopolysaccharides_induced_memory_impairment.pdf R., Zakaria and W. M. H., Wan Yaacob and Z., Othman and I. , Long and A. H. , Ahmad and B. , Al-Rahbi (2017) Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease. Physiological research, 66 (4). pp. 553-565. ISSN 0862-8408 https://search.proquest.com/docview/1953850198? |
| spellingShingle | RC31-1245 Internal medicine R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease |
| title | Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of
Alzheimer’s Disease |
| title_full | Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of
Alzheimer’s Disease |
| title_fullStr | Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of
Alzheimer’s Disease |
| title_full_unstemmed | Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of
Alzheimer’s Disease |
| title_short | Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of
Alzheimer’s Disease |
| title_sort | lipopolysaccharide-induced memory impairment in rats: a model of
alzheimer’s disease |
| topic | RC31-1245 Internal medicine |
| url | http://eprints.usm.my/38100/ http://eprints.usm.my/38100/ http://eprints.usm.my/38100/1/Lipopolysaccharides_induced_memory_impairment.pdf |