Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer
Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of polyADP-ribose polymerase (PARP). However, ther...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Department of Veterinary Services Malaysia
2014
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| Online Access: | http://eprints.usm.my/37411/ http://eprints.usm.my/37411/1/0046353ae8720b3e59000000.pdf |
| _version_ | 1848878184970321920 |
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| author | Rahman, Heshu Sulaiman Abdullah, Rasedee Othman, Hemn Hassan Jalal Ali, Othman Abdul, Ahmad Bustamam Abdul Samad, Nozlena SM, Chartrand Swee, Keong Yeap Hossienpour, Mahnaz |
| author_facet | Rahman, Heshu Sulaiman Abdullah, Rasedee Othman, Hemn Hassan Jalal Ali, Othman Abdul, Ahmad Bustamam Abdul Samad, Nozlena SM, Chartrand Swee, Keong Yeap Hossienpour, Mahnaz |
| author_sort | Rahman, Heshu Sulaiman |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of
cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of
polyADP-ribose polymerase (PARP). However, there has been no available
information of ZER-NLC affects murine breast cancer cells in vivo. Thus, In this
study, in vivo effects of ZER-NLC on murine breast cancer 4T1 cells were
investigated. Outcomes of histopathology, immunohistochemistry and TUNEL assays
of BALB/c mice bearing breast cancer revealed that the number of cancer cells were
significantly decreased in mammary gland tissues after four weeks of oral
administration of various doses of ZER-NLC. |
| first_indexed | 2025-11-15T17:27:19Z |
| format | Article |
| id | usm-37411 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:27:19Z |
| publishDate | 2014 |
| publisher | Department of Veterinary Services Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-374112017-11-15T05:09:55Z http://eprints.usm.my/37411/ Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer Rahman, Heshu Sulaiman Abdullah, Rasedee Othman, Hemn Hassan Jalal Ali, Othman Abdul, Ahmad Bustamam Abdul Samad, Nozlena SM, Chartrand Swee, Keong Yeap Hossienpour, Mahnaz RZ Other systems of medicine Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of polyADP-ribose polymerase (PARP). However, there has been no available information of ZER-NLC affects murine breast cancer cells in vivo. Thus, In this study, in vivo effects of ZER-NLC on murine breast cancer 4T1 cells were investigated. Outcomes of histopathology, immunohistochemistry and TUNEL assays of BALB/c mice bearing breast cancer revealed that the number of cancer cells were significantly decreased in mammary gland tissues after four weeks of oral administration of various doses of ZER-NLC. Department of Veterinary Services Malaysia 2014 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37411/1/0046353ae8720b3e59000000.pdf Rahman, Heshu Sulaiman and Abdullah, Rasedee and Othman, Hemn Hassan and Jalal Ali, Othman and Abdul, Ahmad Bustamam and Abdul Samad, Nozlena and SM, Chartrand and Swee, Keong Yeap and Hossienpour, Mahnaz (2014) Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer. Malaysian Journal of Veterinary Research, 5 (Supt 1). pp. 176-177. ISSN 2180-3897 |
| spellingShingle | RZ Other systems of medicine Rahman, Heshu Sulaiman Abdullah, Rasedee Othman, Hemn Hassan Jalal Ali, Othman Abdul, Ahmad Bustamam Abdul Samad, Nozlena SM, Chartrand Swee, Keong Yeap Hossienpour, Mahnaz Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title | Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title_full | Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title_fullStr | Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title_full_unstemmed | Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title_short | Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer |
| title_sort | antiproliferative efficacy of zerumbone-loaded nanostructured lipid carrier in balb/c mice model of breast cancer |
| topic | RZ Other systems of medicine |
| url | http://eprints.usm.my/37411/ http://eprints.usm.my/37411/1/0046353ae8720b3e59000000.pdf |