The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review
Introduction: There has already been a rising demand in utilising phantom for hybrid Positron Emission Tomography/ Computed Tomography (PET/CT) scanner of nuclear imaging. This review further clarifies this topic and investigates how the previous research phantoms operated with the need for qua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Malaysian Medical Association
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95538/ |
| _version_ | 1848862183658618880 |
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| author | Hanafi, Muhammad Hafiz Mohd Noor, Noramaliza Ahmad Saad, Fathinul Fikri Ramli, Saiful Hasley Mohamed, Faizal Musarudin, Marianie |
| author_facet | Hanafi, Muhammad Hafiz Mohd Noor, Noramaliza Ahmad Saad, Fathinul Fikri Ramli, Saiful Hasley Mohamed, Faizal Musarudin, Marianie |
| author_sort | Hanafi, Muhammad Hafiz |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: There has already been a rising demand in
utilising phantom for hybrid Positron Emission
Tomography/ Computed Tomography (PET/CT) scanner of
nuclear imaging. This review further clarifies this topic and
investigates how the previous research phantoms operated
with the need for quantitative hybrid nuclear imaging of
PET/CT while providing a relatively high image quality when
it was performed. In this article, the necessity of previous
and current phantom studies in hybrid nuclear imaging of
PET/CT scanners is reviewed.
Methods: PubMed and Google Scholar were systematically
searched for the relevant studies by following the PRISMA
2009 checklist. A past decade literature search was
conducted from 2010 until November 2020 to secure the
relevance of the phantom study. Databases were recruited
using keywords such as phantom, quantification,
standardisation, harmonisation, image quality, standardised
uptake value and multicentre study. However, all keywords
were related to PET/CT. All abstracts and eligible full-text
articles were screened independently, and finally, the quality
assessments of this review were performed.
Results: From the 200 retrieved articles, 80 were rejected
after the screening of the abstracts and 35 after reading the
full-text. The 20 accepted articles addressed the distribution
of phantom types used in selected articles studies which
were NEMA (67%), ACR (8%) and others (25%). The articles
showed the various experimental studies, either phantom
studies (35%) or phantom plus clinical studies (65%). For
clinical studies (n = 829), the distribution of prospective
studies was (n = 674) and retrospective studies was (n =155).
The distribution of phantom pathway application showed the
studies focused on 40% of reconstruction protocol studies,
30% of the multicentre and standardisation of accreditation
program studies, and 30% of the quantification of uptake
values studies.
Conclusions: According to this review, the phantom study
have a pivotal role in hybrid nuclear imaging of PET/CT
either in technical aspects of the scanners (such as data
acquisition and reconstruction protocol) or clinical
characteristics of patients. In addition to this, the necessity
to identify the suitable system phantoms to use within PET/CT scans by considering the continuous development
of new phantom studies are needed. Researchers are
encouraged to adopt efforts on phantom quantitative
validation, including verification with clinical data of
patients. |
| first_indexed | 2025-11-15T13:12:59Z |
| format | Article |
| id | upm-95538 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:12:59Z |
| publishDate | 2021 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-955382023-02-07T02:06:32Z http://psasir.upm.edu.my/id/eprint/95538/ The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review Hanafi, Muhammad Hafiz Mohd Noor, Noramaliza Ahmad Saad, Fathinul Fikri Ramli, Saiful Hasley Mohamed, Faizal Musarudin, Marianie Introduction: There has already been a rising demand in utilising phantom for hybrid Positron Emission Tomography/ Computed Tomography (PET/CT) scanner of nuclear imaging. This review further clarifies this topic and investigates how the previous research phantoms operated with the need for quantitative hybrid nuclear imaging of PET/CT while providing a relatively high image quality when it was performed. In this article, the necessity of previous and current phantom studies in hybrid nuclear imaging of PET/CT scanners is reviewed. Methods: PubMed and Google Scholar were systematically searched for the relevant studies by following the PRISMA 2009 checklist. A past decade literature search was conducted from 2010 until November 2020 to secure the relevance of the phantom study. Databases were recruited using keywords such as phantom, quantification, standardisation, harmonisation, image quality, standardised uptake value and multicentre study. However, all keywords were related to PET/CT. All abstracts and eligible full-text articles were screened independently, and finally, the quality assessments of this review were performed. Results: From the 200 retrieved articles, 80 were rejected after the screening of the abstracts and 35 after reading the full-text. The 20 accepted articles addressed the distribution of phantom types used in selected articles studies which were NEMA (67%), ACR (8%) and others (25%). The articles showed the various experimental studies, either phantom studies (35%) or phantom plus clinical studies (65%). For clinical studies (n = 829), the distribution of prospective studies was (n = 674) and retrospective studies was (n =155). The distribution of phantom pathway application showed the studies focused on 40% of reconstruction protocol studies, 30% of the multicentre and standardisation of accreditation program studies, and 30% of the quantification of uptake values studies. Conclusions: According to this review, the phantom study have a pivotal role in hybrid nuclear imaging of PET/CT either in technical aspects of the scanners (such as data acquisition and reconstruction protocol) or clinical characteristics of patients. In addition to this, the necessity to identify the suitable system phantoms to use within PET/CT scans by considering the continuous development of new phantom studies are needed. Researchers are encouraged to adopt efforts on phantom quantitative validation, including verification with clinical data of patients. Malaysian Medical Association 2021-07 Article PeerReviewed Hanafi, Muhammad Hafiz and Mohd Noor, Noramaliza and Ahmad Saad, Fathinul Fikri and Ramli, Saiful Hasley and Mohamed, Faizal and Musarudin, Marianie (2021) The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review. Malaysia Journal of Malaysia, 76 (4). 551 - 561. ISSN 0300-5283 https://www.e-mjm.org/2021/v76n4/index.html |
| spellingShingle | Hanafi, Muhammad Hafiz Mohd Noor, Noramaliza Ahmad Saad, Fathinul Fikri Ramli, Saiful Hasley Mohamed, Faizal Musarudin, Marianie The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title | The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title_full | The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title_fullStr | The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title_full_unstemmed | The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title_short | The need of a system phantom for quantitative hybrid nuclear imaging of PET/CT: a systematic review |
| title_sort | need of a system phantom for quantitative hybrid nuclear imaging of pet/ct: a systematic review |
| url | http://psasir.upm.edu.my/id/eprint/95538/ http://psasir.upm.edu.my/id/eprint/95538/ |