Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka
Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in high demand. Therefore, the main purposed of this study is to evaluate the ne...
| Main Authors: | , , , , |
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| Format: | Article |
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Pakistan Journal of Pharmaceutical Sciences
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94348/ |
| _version_ | 1848861973094072320 |
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| author | Hassan, Ibrahim Maina Wan Ibrahim, Wan Norhamidah Mohamat Yusuf, Ferdaus Ahmad, Siti Aqlima Ahmad, Syahida |
| author_facet | Hassan, Ibrahim Maina Wan Ibrahim, Wan Norhamidah Mohamat Yusuf, Ferdaus Ahmad, Siti Aqlima Ahmad, Syahida |
| author_sort | Hassan, Ibrahim Maina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those
neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in
high demand. Therefore, the main purposed of this study is to evaluate the neuroprotective effects of Curcuma longa
(rhizome) 80% methanol extract. Antioxidant using dichlorofuoresence diacetate (DCF-DA) assay on SH-SY5Y cells
revealed high activities of Curcuma longa (rhizome) extract with IC50 of 105.9±0.8 µg/mL. Sub-acute and chronic
toxicity tests of the plant extract on adult Javanese medaka (Oryzias javanicus) showed high toxicity effect with LC50 of
24.15±0.8 mg/L and 13.69±0.7 mg/L respectively. Neuroprotective tests using cholinesterase assay disclose significant
differences at P<0.05 between the group that are exposed to arsenic and treated with the crude extract and the group that
are exposed to only arsenic. Identification of vitexin and isovitexin justified the high antioxidant potential of this plant
leaf and it highest benefit to be used as medicinal supplement. |
| first_indexed | 2025-11-15T13:09:38Z |
| format | Article |
| id | upm-94348 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:09:38Z |
| publishDate | 2021 |
| publisher | Pakistan Journal of Pharmaceutical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-943482023-04-07T03:47:34Z http://psasir.upm.edu.my/id/eprint/94348/ Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka Hassan, Ibrahim Maina Wan Ibrahim, Wan Norhamidah Mohamat Yusuf, Ferdaus Ahmad, Siti Aqlima Ahmad, Syahida Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in high demand. Therefore, the main purposed of this study is to evaluate the neuroprotective effects of Curcuma longa (rhizome) 80% methanol extract. Antioxidant using dichlorofuoresence diacetate (DCF-DA) assay on SH-SY5Y cells revealed high activities of Curcuma longa (rhizome) extract with IC50 of 105.9±0.8 µg/mL. Sub-acute and chronic toxicity tests of the plant extract on adult Javanese medaka (Oryzias javanicus) showed high toxicity effect with LC50 of 24.15±0.8 mg/L and 13.69±0.7 mg/L respectively. Neuroprotective tests using cholinesterase assay disclose significant differences at P<0.05 between the group that are exposed to arsenic and treated with the crude extract and the group that are exposed to only arsenic. Identification of vitexin and isovitexin justified the high antioxidant potential of this plant leaf and it highest benefit to be used as medicinal supplement. Pakistan Journal of Pharmaceutical Sciences 2021-01 Article PeerReviewed Hassan, Ibrahim Maina and Wan Ibrahim, Wan Norhamidah and Mohamat Yusuf, Ferdaus and Ahmad, Siti Aqlima and Ahmad, Syahida (2021) Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka. Pakistan Journal of Pharmaceutical Sciences, 34 (1). art. no. 7. 47 - 56. ISSN 1011-601X https://www.pjps.pk/single-article/?id=5919 10.36721/PJPS.2021.34.1.REG.047-056.1 |
| spellingShingle | Hassan, Ibrahim Maina Wan Ibrahim, Wan Norhamidah Mohamat Yusuf, Ferdaus Ahmad, Siti Aqlima Ahmad, Syahida Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title | Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title_full | Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title_fullStr | Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title_full_unstemmed | Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title_short | Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka |
| title_sort | neuroprotective and antioxidant effect of curcuma longa (rhizome) methanolic extract on sh-sy5y cells and javanese medaka |
| url | http://psasir.upm.edu.my/id/eprint/94348/ http://psasir.upm.edu.my/id/eprint/94348/ http://psasir.upm.edu.my/id/eprint/94348/ |