Synthesis and biological evaluation of a series of analogues of 2,4,6-trihydroxy-3-geranylacetophenone, an anti-inflammatory natural product compound

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Synthesis and biological evaluation of a series of analogues of 2,4,6-trihydroxy-3-geranylacetophenone, an anti-inflammatory natural product compound

The natural product molecule 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...

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Bibliographic Details
Main Author:	Ng, Chean Hui
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Natural products - Synthesis Organic compound - Synthesis
Online Access:	http://psasir.upm.edu.my/id/eprint/92467/ http://psasir.upm.edu.my/id/eprint/92467/1/IB%202017%208%20UPMIR.pdf

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