Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease?
Cardiovascular disease (CVD) is a serious disease that endangers human health and is one of the leading causes of death. Recent studies have reported that gut microbiota plays an important role in the development of CVD, especially its metabolite trimethylamine-N-oxide (TMAO). Dietary precursors, su...
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/89141/ http://psasir.upm.edu.my/id/eprint/89141/1/GUT.pdf |
| _version_ | 1848860782469578752 |
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| author | He, Mengxue Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa |
| author_facet | He, Mengxue Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa |
| author_sort | He, Mengxue |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cardiovascular disease (CVD) is a serious disease that endangers human health and is one of the leading causes of death. Recent studies have reported that gut microbiota plays an important role in the development of CVD, especially its metabolite trimethylamine-N-oxide (TMAO). Dietary precursors, such as choline, L-carnitine, phosphatidylcholine and betaine were metabolized to trimethylamine (TMA) under the action of gut microbiota, and subsequently oxidized by hepatic flavin monooxygenases (FMOs) to form TMAO. Dietary fat is one of three major nutrients in food, has been found to have a positive or negative effect on the development of CVD. Multiple clinical and experimental evidences suggested that dietary fatty acids (FAs) can affect TMAO production through gut microbiota and/or FMO3 enzyme activity. This article summarizes the existing gut microbiota-mediated reduction of TMA, discusses the molecular mechanism of dietary FAs in the pathobiology of CVD from the view of TMAO. Therefore, this review provides new insight into the association of dietary FAs and CVD, paving the way for dietary FAs therapy for CVD. |
| first_indexed | 2025-11-15T12:50:42Z |
| format | Article |
| id | upm-89141 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:50:42Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-891412021-09-04T00:04:17Z http://psasir.upm.edu.my/id/eprint/89141/ Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? He, Mengxue Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa Cardiovascular disease (CVD) is a serious disease that endangers human health and is one of the leading causes of death. Recent studies have reported that gut microbiota plays an important role in the development of CVD, especially its metabolite trimethylamine-N-oxide (TMAO). Dietary precursors, such as choline, L-carnitine, phosphatidylcholine and betaine were metabolized to trimethylamine (TMA) under the action of gut microbiota, and subsequently oxidized by hepatic flavin monooxygenases (FMOs) to form TMAO. Dietary fat is one of three major nutrients in food, has been found to have a positive or negative effect on the development of CVD. Multiple clinical and experimental evidences suggested that dietary fatty acids (FAs) can affect TMAO production through gut microbiota and/or FMO3 enzyme activity. This article summarizes the existing gut microbiota-mediated reduction of TMA, discusses the molecular mechanism of dietary FAs in the pathobiology of CVD from the view of TMAO. Therefore, this review provides new insight into the association of dietary FAs and CVD, paving the way for dietary FAs therapy for CVD. Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89141/1/GUT.pdf He, Mengxue and Tan, Chin Ping and Xu, Yong Jiang and Liu, Yuanfa (2020) Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? Food Research International, 138 (pt. 8). art. no. 109812. pp. 1-9. ISSN 0963-9969 https://www.sciencedirect.com/science/article/pii/S0963996920308371 10.1016/j.foodres.2020.109812 |
| spellingShingle | He, Mengxue Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title | Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title_full | Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title_fullStr | Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title_full_unstemmed | Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title_short | Gut microbiota-derived trimethylamine-N-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| title_sort | gut microbiota-derived trimethylamine-n-oxide: a bridge between dietary fatty acid and cardiovascular disease? |
| url | http://psasir.upm.edu.my/id/eprint/89141/ http://psasir.upm.edu.my/id/eprint/89141/ http://psasir.upm.edu.my/id/eprint/89141/ http://psasir.upm.edu.my/id/eprint/89141/1/GUT.pdf |