Novel drug delivery systems for loading of natural plant extracts and their biomedical applications
Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/86923/ http://psasir.upm.edu.my/id/eprint/86923/1/Novel%20drug%20delivery%20systems%20for.pdf |
| _version_ | 1848860322028322816 |
|---|---|
| author | Rahman, Heshu Sulaiman Othman, Hemn Hassan Hammadi, Nahidah Ibrahim Swee, Keong Yeap Mohammad Amin, Kawa Abdul Samad, Nozlena Mohammed Alitheen, Noorjahan Banu |
| author_facet | Rahman, Heshu Sulaiman Othman, Hemn Hassan Hammadi, Nahidah Ibrahim Swee, Keong Yeap Mohammad Amin, Kawa Abdul Samad, Nozlena Mohammed Alitheen, Noorjahan Banu |
| author_sort | Rahman, Heshu Sulaiman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications. |
| first_indexed | 2025-11-15T12:43:23Z |
| format | Article |
| id | upm-86923 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:43:23Z |
| publishDate | 2020 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-869232022-01-03T04:18:46Z http://psasir.upm.edu.my/id/eprint/86923/ Novel drug delivery systems for loading of natural plant extracts and their biomedical applications Rahman, Heshu Sulaiman Othman, Hemn Hassan Hammadi, Nahidah Ibrahim Swee, Keong Yeap Mohammad Amin, Kawa Abdul Samad, Nozlena Mohammed Alitheen, Noorjahan Banu Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications. Dove Medical Press 2020-04-15 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86923/1/Novel%20drug%20delivery%20systems%20for.pdf Rahman, Heshu Sulaiman and Othman, Hemn Hassan and Hammadi, Nahidah Ibrahim and Swee, Keong Yeap and Mohammad Amin, Kawa and Abdul Samad, Nozlena and Mohammed Alitheen, Noorjahan Banu (2020) Novel drug delivery systems for loading of natural plant extracts and their biomedical applications. International Journal of Nanomedicine, 2020 (15). 2439 - 2483. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/novel-drug-delivery-systems-for-loading-of-natural-plant-extracts-and--peer-reviewed-fulltext-article-IJN 10.2147/IJN.S227805 |
| spellingShingle | Rahman, Heshu Sulaiman Othman, Hemn Hassan Hammadi, Nahidah Ibrahim Swee, Keong Yeap Mohammad Amin, Kawa Abdul Samad, Nozlena Mohammed Alitheen, Noorjahan Banu Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title | Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title_full | Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title_fullStr | Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title_full_unstemmed | Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title_short | Novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| title_sort | novel drug delivery systems for loading of natural plant extracts and their biomedical applications |
| url | http://psasir.upm.edu.my/id/eprint/86923/ http://psasir.upm.edu.my/id/eprint/86923/ http://psasir.upm.edu.my/id/eprint/86923/ http://psasir.upm.edu.my/id/eprint/86923/1/Novel%20drug%20delivery%20systems%20for.pdf |